Systematic deletion of rRNAs for investigating ribosome architecture and function.

Kei Kitahara, Neuza S. Sato, Naoki Namba, Takuya Yokota, Tarou Tsujimura, Tsutomu Suzuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Ribosomal RNAs (rRNAs) form a fundamental structure of ribosome, and play crucial roles in protein biosynthesis. To investigate functional importance of RNA helices in both 16S and 23S rRNAs, we devised an E. coli genetic system that allowed us to identify and select functional deletions in rRNAs. We here describe many RNA helices in rRNAs to be shortened or completely truncated. These results suggest architectural flexibility of rRNAs in ribosome assembly and function.

Original languageEnglish
Pages (from-to)287-288
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number50
Publication statusPublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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