Tachykinin receptor 3 distribution in human oral squamous cell carcinoma

Kyoichi Obata; Tsuyoshi Shimo; Tatsuo Okui; Kenichi Matsumoto; Hiroyuki Takada; Kiyofumi Takabatake; Yuki Kunisada; Soichiro Ibaragi; Hitoshi Nagatsuka; Akira Sasaki

doi:10.21873/anticanres.11230

Tachykinin receptor 3 distribution in human oral squamous cell carcinoma

Kyoichi Obata, Tsuyoshi Shimo, Tatsuo Okui, Kenichi Matsumoto, Hiroyuki Takada, Kiyofumi Takabatake, Yuki Kunisada, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown. Materials and Methods: We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis. Results: We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible. Conclusion: Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.

Original language	English
Pages (from-to)	6335-6341
Number of pages	7
Journal	Anticancer research
Volume	36
Issue number	12
DOIs	https://doi.org/10.21873/anticanres.11230
Publication status	Published - Dec 2016

Keywords

Oral squamous cell carcinoma
Tachykinin 3
Tachykinin receptor 3

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.11230

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title = "Tachykinin receptor 3 distribution in human oral squamous cell carcinoma",

abstract = "Background: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown. Materials and Methods: We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis. Results: We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible. Conclusion: Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.",

keywords = "Oral squamous cell carcinoma, Tachykinin 3, Tachykinin receptor 3",

author = "Kyoichi Obata and Tsuyoshi Shimo and Tatsuo Okui and Kenichi Matsumoto and Hiroyuki Takada and Kiyofumi Takabatake and Yuki Kunisada and Soichiro Ibaragi and Hitoshi Nagatsuka and Akira Sasaki",

year = "2016",

month = dec,

doi = "10.21873/anticanres.11230",

language = "English",

volume = "36",

pages = "6335--6341",

journal = "Anticancer research",

issn = "0250-7005",

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T1 - Tachykinin receptor 3 distribution in human oral squamous cell carcinoma

AU - Obata, Kyoichi

AU - Shimo, Tsuyoshi

AU - Okui, Tatsuo

AU - Matsumoto, Kenichi

AU - Takada, Hiroyuki

AU - Takabatake, Kiyofumi

AU - Kunisada, Yuki

AU - Ibaragi, Soichiro

AU - Nagatsuka, Hitoshi

AU - Sasaki, Akira

PY - 2016/12

Y1 - 2016/12

N2 - Background: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown. Materials and Methods: We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis. Results: We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible. Conclusion: Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.

AB - Background: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown. Materials and Methods: We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis. Results: We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible. Conclusion: Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.

KW - Oral squamous cell carcinoma

KW - Tachykinin 3

KW - Tachykinin receptor 3

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Tachykinin receptor 3 distribution in human oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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