Targeting angiogenesis in cancer therapy

Eiki Ichihara, Katsuyuki Kiura, Mitsune Tanimoto

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a target of cancer therapy. In subsequent decades, numerous antiangiogenic agents were developed, and some of them have been applied clinically. However, angiogenesis includes a complex and multistep process that has not been sufficiently elucidated. In this review, we focus on signaling pathways related with tumor angiogenesis and several antiangiogenic agents approved by the United States Food and Drug Administration or under investigation.

Original languageEnglish
Pages (from-to)353-362
Number of pages10
JournalActa medica Okayama
Issue number6
Publication statusPublished - Dec 22 2011


  • Angiogenesis
  • Cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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