TY - JOUR
T1 - TE-031 in urethritis
AU - Kishi, Mikio
AU - Yamada, Daisuke
AU - Nasu, Yoshitsugu
AU - Tsugawa, Masaya
AU - Kumon, Hiromi
AU - Ohmori, Hiroyuki
AU - Kondo, Katsuyoshi
AU - Kondo, Atsushi
AU - Nanba, Katsuichi
PY - 1988/1/1
Y1 - 1988/1/1
N2 - We performed a clinical study on TE-031 in urethritis and obtained the following results. 1. In 5 cases of gonococcal urethritis, clinical efficacy rates by doctor's evaluation, criteria proposed by the Trial Committee (Trial Criteria) and our own criteria were 40.0%, 80.0% and 40.0%, respectively. 2. In 13 cases of chlamydial urethritis, the three clinical efficacy rates were 92.3%, 91.7% and 77.8%, respectively. 3. In 6 cases of non-gonococcal and non-chlamydial urethritis, clinical efficacy rate by the doctor's evaluation and our criteria was 66.7% and 50.0%, respectively. 4. Bacteriologically, 4 of 5 strains of N. gonorrhoeae, and all 13 strains of C. trachomatis were eradicated. 5. Side-effects were observed in two cases, showing mild gastric discomfort. No abnormal laboratory findings were observed. Consequently, we found TE-031 less effective than other drugs such as β-lactams and SPCM for gonococcal urethritis, but clearly effective in non-gonococcal urethritis.
AB - We performed a clinical study on TE-031 in urethritis and obtained the following results. 1. In 5 cases of gonococcal urethritis, clinical efficacy rates by doctor's evaluation, criteria proposed by the Trial Committee (Trial Criteria) and our own criteria were 40.0%, 80.0% and 40.0%, respectively. 2. In 13 cases of chlamydial urethritis, the three clinical efficacy rates were 92.3%, 91.7% and 77.8%, respectively. 3. In 6 cases of non-gonococcal and non-chlamydial urethritis, clinical efficacy rate by the doctor's evaluation and our criteria was 66.7% and 50.0%, respectively. 4. Bacteriologically, 4 of 5 strains of N. gonorrhoeae, and all 13 strains of C. trachomatis were eradicated. 5. Side-effects were observed in two cases, showing mild gastric discomfort. No abnormal laboratory findings were observed. Consequently, we found TE-031 less effective than other drugs such as β-lactams and SPCM for gonococcal urethritis, but clearly effective in non-gonococcal urethritis.
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U2 - 10.11250/chemotherapy1953.36.Supplement3_842
DO - 10.11250/chemotherapy1953.36.Supplement3_842
M3 - Article
AN - SCOPUS:0023735173
SN - 0009-3165
VL - 36
SP - 842
EP - 849
JO - Chemotherapy
JF - Chemotherapy
ER -
