TY - JOUR
T1 - Tectona grandis callus produces antibacterial triterpene acids not detected in the intact plant
AU - Marwani, E.
AU - Kobayashi, A.
AU - Kajiyama, S. I.
AU - Fukusaki, E.
AU - Nitoda, T.
AU - Kanzaki, H.
AU - Kawazu, K.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Preliminary antibacterial assay data that the Tectona grandis callus extract showed more antibacterial activity against E. coli and B. subtilis than the leaf extract led the authors to isolate the following antibacterial compounds from the callus. A mixture (3) of 2α,3β-dihydroxy-olean-12-en-28-oic acid (3b) and 2α,3β-dihydroxy-urs-12-en-28-oic acid (3b) exhibited the most potent antibacterial activity against both bacteria. The other 3 compounds, in the decreasing order of the activity, were identified as 2α,3α-dihydroxy-urs-12-en-28-oic acid (2), betulinic acid (1), and 2α,3α 23-trihydroxy-urs-12-en-28-oic acid (4). The antibacterial compounds (2, 3a, 3b and 4) were not detected or occurring in small quantities in the intact tissue, while they were observed in the callus. Only the less active compound 1 was present more abundantly in intact tissues than the callus.
AB - Preliminary antibacterial assay data that the Tectona grandis callus extract showed more antibacterial activity against E. coli and B. subtilis than the leaf extract led the authors to isolate the following antibacterial compounds from the callus. A mixture (3) of 2α,3β-dihydroxy-olean-12-en-28-oic acid (3b) and 2α,3β-dihydroxy-urs-12-en-28-oic acid (3b) exhibited the most potent antibacterial activity against both bacteria. The other 3 compounds, in the decreasing order of the activity, were identified as 2α,3α-dihydroxy-urs-12-en-28-oic acid (2), betulinic acid (1), and 2α,3α 23-trihydroxy-urs-12-en-28-oic acid (4). The antibacterial compounds (2, 3a, 3b and 4) were not detected or occurring in small quantities in the intact tissue, while they were observed in the callus. Only the less active compound 1 was present more abundantly in intact tissues than the callus.
KW - Antibacterial compounds
KW - Lupene
KW - Oleanene
KW - Tectona grandis callus
KW - Triterpene acids
KW - Ursene
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M3 - Article
AN - SCOPUS:0030802845
SN - 1226-3907
VL - 3
SP - 75
EP - 80
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 1
ER -