Terahertz aptasensor for dopamine neurochemical detection

Jin Wang; Kosei Morita; Masaki Ando; Sota Yoshida; Hiroki Nagata; Kenji Sakai; Toshihiko Kiwa

doi:10.35848/1882-0786/acd102

Terahertz aptasensor for dopamine neurochemical detection

Jin Wang, Kosei Morita, Masaki Ando, Sota Yoshida, Hiroki Nagata, Kenji Sakai, Toshihiko Kiwa

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

Measuring neurotransmitter levels in the body can identify imbalances and diagnose neurological and psychiatric disorders. Several advanced imaging technologies and electrochemical and optical sensors have been developed for a highly sensitive and selective detection of neurotransmitters. In this study, a terahertz chemical microscope (TCM) for measurement of dopamine levels is proposed. The TCM uses terahertz waves to obtain a label-free chemical reaction on a sensing plate. A DNA aptamer is investigated as a recognition element for detection of dopamine. The measurement mechanism and construction of the terahertz aptasensor are described, providing a potential alternative for neurotransmitter detection.

Original language	English
Article number	052002
Journal	Applied Physics Express
Volume	16
Issue number	5
DOIs	https://doi.org/10.35848/1882-0786/acd102
Publication status	Published - May 1 2023

Keywords

DNA aptamer
dopamine neurochemical
terahertz chemical microscope

ASJC Scopus subject areas

General Engineering
General Physics and Astronomy

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10.35848/1882-0786/acd102

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title = "Terahertz aptasensor for dopamine neurochemical detection",

abstract = "Measuring neurotransmitter levels in the body can identify imbalances and diagnose neurological and psychiatric disorders. Several advanced imaging technologies and electrochemical and optical sensors have been developed for a highly sensitive and selective detection of neurotransmitters. In this study, a terahertz chemical microscope (TCM) for measurement of dopamine levels is proposed. The TCM uses terahertz waves to obtain a label-free chemical reaction on a sensing plate. A DNA aptamer is investigated as a recognition element for detection of dopamine. The measurement mechanism and construction of the terahertz aptasensor are described, providing a potential alternative for neurotransmitter detection.",

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T1 - Terahertz aptasensor for dopamine neurochemical detection

AU - Wang, Jin

AU - Morita, Kosei

AU - Ando, Masaki

AU - Yoshida, Sota

AU - Nagata, Hiroki

AU - Sakai, Kenji

AU - Kiwa, Toshihiko

PY - 2023/5/1

Y1 - 2023/5/1

N2 - Measuring neurotransmitter levels in the body can identify imbalances and diagnose neurological and psychiatric disorders. Several advanced imaging technologies and electrochemical and optical sensors have been developed for a highly sensitive and selective detection of neurotransmitters. In this study, a terahertz chemical microscope (TCM) for measurement of dopamine levels is proposed. The TCM uses terahertz waves to obtain a label-free chemical reaction on a sensing plate. A DNA aptamer is investigated as a recognition element for detection of dopamine. The measurement mechanism and construction of the terahertz aptasensor are described, providing a potential alternative for neurotransmitter detection.

AB - Measuring neurotransmitter levels in the body can identify imbalances and diagnose neurological and psychiatric disorders. Several advanced imaging technologies and electrochemical and optical sensors have been developed for a highly sensitive and selective detection of neurotransmitters. In this study, a terahertz chemical microscope (TCM) for measurement of dopamine levels is proposed. The TCM uses terahertz waves to obtain a label-free chemical reaction on a sensing plate. A DNA aptamer is investigated as a recognition element for detection of dopamine. The measurement mechanism and construction of the terahertz aptasensor are described, providing a potential alternative for neurotransmitter detection.

KW - DNA aptamer

KW - dopamine neurochemical

KW - terahertz chemical microscope

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Terahertz aptasensor for dopamine neurochemical detection

Abstract

Keywords

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