The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

Tomonori Tateishi; Hironori Nakura; Minoru Watanabe; Masami Tanaka; Toshio Kumai; Shinichi Kobayashi

doi:10.1016/S0304-3835(96)04361-3

The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

Tomonori Tateishi, Hironori Nakura, Minoru Watanabe, Masami Tanaka, Toshio Kumai, Shinichi Kobayashi

Research output: Contribution to journal › Article › peer-review

Abstract

We estimate the influence of five 5-hydroxytryptamine receptor (5-HT₃) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT₃ antagonists. DPDase activity was not altered in the presence of any 5-HT₃ antagonist studied here. It may be inferred from these results that the any 5-HT₃ receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Cancer Letters
Volume	108
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(96)04361-3
Publication status	Published - Nov 12 1996
Externally published	Yes

Keywords

5-fluorouracil
5-hyroxytrypamine antagonists
Dihydropyrimide dehydrogenase
Rat liver cytosol

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(96)04361-3

Cite this

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abstract = "We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.",

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AU - Tateishi, Tomonori

AU - Nakura, Hironori

AU - Watanabe, Minoru

AU - Tanaka, Masami

AU - Kumai, Toshio

AU - Kobayashi, Shinichi

PY - 1996/11/12

Y1 - 1996/11/12

N2 - We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

AB - We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

KW - 5-fluorouracil

KW - 5-hyroxytrypamine antagonists

KW - Dihydropyrimide dehydrogenase

KW - Rat liver cytosol

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The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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