Katsuyama et al. find that an expanded CD8CD38high T cell population in SLE patients is linked to infections. CD8CD38high T cells display decreased cytotoxic capacity by suppressing the expression of related molecules through an NAD+/Sirtuin1/EZH2 pathway. EZH2 inhibitors increase cytotoxicity offering a means to mitigate infection rates in SLE.
- CD8 T cell
- nicotinamide adenine dinucleotide
- systemic lupus erythematosus
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology