@article{6ba1274c933d49478d04b2ccdef4aa22,
title = "The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections",
abstract = "Katsuyama et al. find that an expanded CD8CD38high T cell population in SLE patients is linked to infections. CD8CD38high T cells display decreased cytotoxic capacity by suppressing the expression of related molecules through an NAD+/Sirtuin1/EZH2 pathway. EZH2 inhibitors increase cytotoxicity offering a means to mitigate infection rates in SLE.",
keywords = "CD38, CD8 T cell, EZH2, Sirtuin1, cytotoxicity, infection, nicotinamide adenine dinucleotide, patients, systemic lupus erythematosus",
author = "Eri Katsuyama and Abel Suarez-Fueyo and Bradley, {Sean J.} and Masayuki Mizui and Marin, {Ana V.} and Lama Mulki and Suzanne Krishfield and Fabio Malavasi and Joon Yoon and Sui, {Shannan J.Ho} and Kyttaris, {Vasileios C.} and Tsokos, {George C.}",
note = "Funding Information: This work was supported by National Institutes of Health ( NIH ) grants RO1 AI42269 and RO1 AI148161 to G.C.T. We are also extremely grateful to all patients participating in our ongoing SLE studies. Funding Information: This work was supported by National Institutes of Health (NIH) grants RO1 AI42269 and RO1 AI148161 to G.C.T. We are also extremely grateful to all patients participating in our ongoing SLE studies. Conceptualization, E.K. A.S.-F. S.J.B. and G.C.T.; Methodology, E.K. A.S.-F. S.J.B. V.C.K. F.M. and G.C.T.; Investigation, E.K. A.S.-F. S.J.B. V.C.K. M.M. L.M. A.V.M. and S.K.; Formal Analysis, E.K. A.S.-F. S.J.B. V.C.K. J.Y. and S.J.H.S.; Writing?Original Draft, E.K. A.S.-F. and G.C.T.; Writing?Review & Editing, E.K. V.C.K. F.M. H.S.S. and G.C.T.; Funding Acquisition, G.C.T.; Resources, F.M.; Supervision, G.C.T. G.C.T. is on the Scientific Advisory Board (SAB) of A2 Therapeutics, ABPRO, and CUGENE and has received research grants from Janssen and Pfizer. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2020",
month = jan,
day = "7",
doi = "10.1016/j.celrep.2019.12.014",
language = "English",
volume = "30",
pages = "112--123.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}