The clinical application of hydrogen as a medical treatment

Atsuyoshi Iida, Nobuyuki Nosaka, Tetsuya Yumoto, Emily Knaup, Hiromichi Naito, Chihiro Nishiyama, Yasuaki Yamakawa, Kohei Tsukahara, Michihisa Terado, Keiji Sato, Toyomu Ugawa, Atsunori Nkao

Research output: Contribution to journalReview articlepeer-review

60 Citations (Scopus)


In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogen's effectiveness is thus multifaceted. Herein we review the recent research on hydrogen-rich water, and we examine the possibilities for its clinical application. Now that hydrogen is in the limelight as a gaseous signaling molecule due to its potential ability to inhibit oxidative stress signaling, new research developments are highly anticipated.

Original languageEnglish
Pages (from-to)331-338
Number of pages8
JournalActa medica Okayama
Issue number5
Publication statusPublished - 2016


  • Antioxidant effect
  • Clinical tests
  • Gaseous signaling molecule
  • Hydrogen
  • Medical gas

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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