TY - JOUR
T1 - The clinical course of Rathke’s cleft cysts in pediatric patients
T2 - impact on growth and pubertal development
AU - Higuchi, Yousuke
AU - Hasegawa, Kosei
AU - Kubo, Toshihide
AU - Tanaka, Hiroyuki
AU - Tsukahara, Hirokazu
N1 - Funding Information:
This study was supported by a grant from the Foundation for Growth Science (H28-46), Japan. We would like to thank Editage (www.editage.com) for English language editing.
Publisher Copyright:
© 2022, Jeff Corporation Co. Ltd. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Rathke’s cleft cysts (RCCs) are non-neoplastic epithelial lesions in the sellar or suprasellar regions. RCCs are usually asymptomatic; however, some patients experience headaches, visual disturbances, and endocrine disorders. The best treatment for associated endocrinopathy remains elusive. We aimed to investigate the clinical course, magnetic resonance imaging findings, and response to therapy in 10 pediatric patients with RCCs and endocrinopathy. Growth impairment and precocious puberty were observed to be prevalent. One patient with suprasellar extension of RCC underwent surgery, while the others were treated medically. Of the nine patients, seven patients showed stable cyst size, while two patients displayed reduction in cyst size. Hormone replacement and gonadotropin suppression therapy were found to be effective. Imaging and endocrine follow-ups are warranted because of the potential for changes in the cyst size and hormonal changes.
AB - Rathke’s cleft cysts (RCCs) are non-neoplastic epithelial lesions in the sellar or suprasellar regions. RCCs are usually asymptomatic; however, some patients experience headaches, visual disturbances, and endocrine disorders. The best treatment for associated endocrinopathy remains elusive. We aimed to investigate the clinical course, magnetic resonance imaging findings, and response to therapy in 10 pediatric patients with RCCs and endocrinopathy. Growth impairment and precocious puberty were observed to be prevalent. One patient with suprasellar extension of RCC underwent surgery, while the others were treated medically. Of the nine patients, seven patients showed stable cyst size, while two patients displayed reduction in cyst size. Hormone replacement and gonadotropin suppression therapy were found to be effective. Imaging and endocrine follow-ups are warranted because of the potential for changes in the cyst size and hormonal changes.
KW - Central precocious puberty
KW - GH deficiency
KW - Pituitary imaging
KW - Rathke’s cleft cysts
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U2 - 10.1297/cpe.2021-0034
DO - 10.1297/cpe.2021-0034
M3 - Article
AN - SCOPUS:85126108424
SN - 0918-5739
VL - 31
SP - 38
EP - 43
JO - clinical pediatric endocrinology
JF - clinical pediatric endocrinology
IS - 1
ER -
