The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke

Kazuhiko Nakano, Kazuya Hokamura, Naho Taniguchi, Koichiro Wada, Chiho Kudo, Ryota Nomura, Ayuchi Kojima, Shuhei Naka, Yoshinori Muranaka, Min Thura, Atsushi Nakajima, Katsuhiko Masuda, Ichiro Nakagawa, Pietro Speziale, Nobumitsu Shimada, Atsuo Amano, Yoshinori Kamisaki, Tokutaro Tanaka, Kazuo Umemura, Takashi Ooshima

Research output: Contribution to journalArticlepeer-review

121 Citations (Scopus)


Although several risk factors for stroke have been identified, one-third remain unexplained. Here we show that infection with Streptococcus mutans expressing collagen-binding protein (CBP) is a potential risk factor for haemorrhagic stroke. Infection with serotype k S. mutans, but not a standard strain, aggravates cerebral haemorrhage in mice. Serotype k S. mutans accumulates in the damaged, but not the contralateral hemisphere, indicating an interaction of bacteria with injured blood vessels. The most important factor for high-virulence is expression of CBP, which is a common property of most serotype k strains. The detection frequency of CBP-expressing S. mutans in haemorrhagic stroke patients is significantly higher than in control subjects. Strains isolated from haemorrhagic stroke patients aggravate haemorrhage in a mouse model, indicating that they are haemorrhagic stroke-associated. Administration of recombinant CBP causes aggravation of haemorrhage. Our data suggest that CBP of S. mutans is directly involved in haemorrhagic stroke.

Original languageEnglish
Article number485
JournalNature communications
Issue number1
Publication statusPublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke'. Together they form a unique fingerprint.

Cite this