The critical role of the antimicrobial peptide LL-37/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis

Meihua Zhang; Weiwei Liang; Wanghua Gong; Teizo Yoshimura; Keqiang Chen; Ji Ming Wang

doi:10.1615/CritRevImmunol.2019030225

The critical role of the antimicrobial peptide LL-37/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis

Meihua Zhang, Weiwei Liang, Wanghua Gong, Teizo Yoshimura, Keqiang Chen, Ji Ming Wang

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Mouse cathelin-related antimicrobial peptide (CRAMP) and its homologue human cathelicidin (LL-37) play active roles in innate immune responses, angiogenesis, and wound healing. In addition, LL-37/CRAMP fends off microbes and protects against infections in the colon, where the epithelium is exposed to myriad of enteric pathogens. It is increasingly recognized that LL-37/CRAMP maintains colon mucosal barrier integrity, shapes the composition of microbiota, and protects the host from tumorigenesis. In this review, we discuss the importance of LL-37/CRAMP in the homeostasis of the host, with novel findings derived from mice deficient in CRAMP that support the proposition for this natural antimicrobial peptide and an immune modulator as a drug lead for therapeutic development.

Original language	English
Pages (from-to)	83-92
Number of pages	10
Journal	Critical Reviews in Immunology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1615/CritRevImmunol.2019030225
Publication status	Published - 2019

Keywords

CRAMP
Cancer
Colitis
Homeostasis
Microbiota

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1615/CritRevImmunol.2019030225

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The critical role of the antimicrobial peptide LL-37/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis. / Zhang, Meihua; Liang, Weiwei; Gong, Wanghua et al.
In: Critical Reviews in Immunology, Vol. 39, No. 2, 2019, p. 83-92.

Research output: Contribution to journal › Article › peer-review

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note = "Funding Information: The authors thank Dr. Joost J. Oppenheim for reviewing the manuscript and Ms. Cheri Rhoderick for secretarial assistance. This study was supported in part by federal funds from the National Cancer Institute (NCI), National Institutes of Health (NIH), under Contract No. HHSN261200800001E and was supported in part by the Intramural Research Program of the NCI, NIH. M.Z. was also supported in part by a fund from the National Natural Science Foundation, Project 81873842. Publisher Copyright: {\textcopyright} 2019 Begell House, Inc.",

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The critical role of the antimicrobial peptide LL-37/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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