The cyclins: A family of widely expressed tumor antigens?

Michael S. Von Bergwelt-Baildon; Eisei Kondo; Nela Klein-Gonźlez; Clemens M. Wendtner

doi:10.1586/erv.10.170

The cyclins: A family of widely expressed tumor antigens?

Michael S. Von Bergwelt-Baildon, Eisei Kondo, Nela Klein-Gonźlez, Clemens M. Wendtner

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent relevant target molecules for tumor therapy. Among these targets the cyclins are of particular interest as they are overexpressed in various tumor entities with little expression in normal tissue. Here we review evidence that these molecules are recognized by the immune system, summarize why cyclins A, B and D in particular appear to be interesting targets for active and passive immunotherapy, and discuss whether the entire family could be an interesting novel class of tumor antigens for cancer treatment and prevention.

Original language	English
Pages (from-to)	389-395
Number of pages	7
Journal	Expert Review of Vaccines
Volume	10
Issue number	3
DOIs	https://doi.org/10.1586/erv.10.170
Publication status	Published - Mar 2011
Externally published	Yes

Keywords

T-cell epitopes
active immunotherapy
cyclin
tumor antigens

ASJC Scopus subject areas

Immunology
Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/erv.10.170

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title = "The cyclins: A family of widely expressed tumor antigens?",

abstract = "Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent relevant target molecules for tumor therapy. Among these targets the cyclins are of particular interest as they are overexpressed in various tumor entities with little expression in normal tissue. Here we review evidence that these molecules are recognized by the immune system, summarize why cyclins A, B and D in particular appear to be interesting targets for active and passive immunotherapy, and discuss whether the entire family could be an interesting novel class of tumor antigens for cancer treatment and prevention.",

keywords = "T-cell epitopes, active immunotherapy, cyclin, tumor antigens",

author = "{Von Bergwelt-Baildon}, {Michael S.} and Eisei Kondo and Nela Klein-Gon{\'z}lez and Wendtner, {Clemens M.}",

note = "Funding Information: Supported by a Max Eder Junior Research Grant from the German Cancer Aid (Deutsche Krebshilfe) by the Else Kr{\"o}ner Fresenius-Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2011",

month = mar,

doi = "10.1586/erv.10.170",

language = "English",

volume = "10",

pages = "389--395",

journal = "Expert Review of Vaccines",

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T1 - The cyclins

T2 - A family of widely expressed tumor antigens?

AU - Von Bergwelt-Baildon, Michael S.

AU - Kondo, Eisei

AU - Klein-Gonźlez, Nela

AU - Wendtner, Clemens M.

N1 - Funding Information: Supported by a Max Eder Junior Research Grant from the German Cancer Aid (Deutsche Krebshilfe) by the Else Kröner Fresenius-Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2011/3

Y1 - 2011/3

N2 - Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent relevant target molecules for tumor therapy. Among these targets the cyclins are of particular interest as they are overexpressed in various tumor entities with little expression in normal tissue. Here we review evidence that these molecules are recognized by the immune system, summarize why cyclins A, B and D in particular appear to be interesting targets for active and passive immunotherapy, and discuss whether the entire family could be an interesting novel class of tumor antigens for cancer treatment and prevention.

AB - Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent relevant target molecules for tumor therapy. Among these targets the cyclins are of particular interest as they are overexpressed in various tumor entities with little expression in normal tissue. Here we review evidence that these molecules are recognized by the immune system, summarize why cyclins A, B and D in particular appear to be interesting targets for active and passive immunotherapy, and discuss whether the entire family could be an interesting novel class of tumor antigens for cancer treatment and prevention.

KW - T-cell epitopes

KW - active immunotherapy

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KW - tumor antigens

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The cyclins: A family of widely expressed tumor antigens?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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