The effects of methylglyoxal on glutathione s-transferase from nicotiana tabacum

Md Anamul Hoque, Misugi Uraji, Mst Nasrin Akhter Banu, Izumi C. Mori, Yoshimasa Nakamura, Yoshiyuki Murata

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Methylglyoxal (MG) is one of the aldehydes that accumulate in plants under environmental stress. Glutathione S-transferases (GSTs) play important roles, including detoxification, in the stress tolerance systems of plants. To determine the effects of MG, we characterized recombinant GST. MG decreased GST activity and thiol contents with increasing Km. GST can serve as a target of MG modification, which is suppressed by application of reduced glutathione.

Original languageEnglish
Pages (from-to)2124-2126
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number10
Publication statusPublished - 2010


  • 1-chloro-2,4-dinitrobenzene
  • Glutathione
  • Glutathione s-transferase
  • Methylglyoxal
  • Thiol

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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