TY - JOUR
T1 - The function of dynamin in endocytosis
AU - De Camilli, Pietro
AU - Takei, Kohji
AU - McPherson, Peter S.
PY - 1995/10
Y1 - 1995/10
N2 - Temperature-sensitive shibire mutants of Drosophila melanogaster become rapidly paralyzed upon a shift to the restrictive temperature, which is due to a block in synaptic vesicle endocytosis. The shibire gene encodes the GTPase dynamin. Recent studies have shown that dynamin forms rings at the neck of invaginated clathrin-coated pits, and have suggested that a conformational change in the ring, which correlates with GTP hydrolysis, plays an essential role in vesicle fission.
AB - Temperature-sensitive shibire mutants of Drosophila melanogaster become rapidly paralyzed upon a shift to the restrictive temperature, which is due to a block in synaptic vesicle endocytosis. The shibire gene encodes the GTPase dynamin. Recent studies have shown that dynamin forms rings at the neck of invaginated clathrin-coated pits, and have suggested that a conformational change in the ring, which correlates with GTP hydrolysis, plays an essential role in vesicle fission.
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U2 - 10.1016/0959-4388(95)80059-X
DO - 10.1016/0959-4388(95)80059-X
M3 - Article
C2 - 8580706
AN - SCOPUS:0028866565
SN - 0959-4388
VL - 5
SP - 559
EP - 565
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -