TY - JOUR
T1 - The hematopoietic stem cell niche
T2 - From embryo to adult
AU - Gao, Xin
AU - Xu, Chunliang
AU - Asada, Noboru
AU - Frenette, Paul S.
N1 - Funding Information:
We apologize to the investigators whose work could not be cited owing to space limitation.We thank the National Institutes of Health (DK056638, HL069438), the Leukemia and Lymphoma Society (LLS-TRP 6475-15) and the New York State Department of Health (NYSTEM IIRP C029570 and C029154) for their support of our laboratory. Deposited in PMC for release after 12 months.
Publisher Copyright:
© 2018. Published by The Company of Biologists Ltd.
PY - 2018/1/15
Y1 - 2018/1/15
N2 - Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.
AB - Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.
KW - Bone marrow
KW - Hematopoietic stem cell
KW - Hemogenic endothelium
KW - Microenvironment
KW - Niche
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U2 - 10.1242/dev.139691
DO - 10.1242/dev.139691
M3 - Review article
C2 - 29358215
AN - SCOPUS:85041317160
SN - 0950-1991
VL - 145
JO - Development (Cambridge)
JF - Development (Cambridge)
IS - 2
M1 - dev139691
ER -