TY - JOUR
T1 - The impact of prognostic nutrition index on the waitlist mortality of lung transplantation
AU - Matsubara, Kei
AU - Otani, Shinji
AU - Yamamoto, Haruchika
AU - Tomioka, Yasuaki
AU - Shiotani, Toshio
AU - Miyoshi, Kentaroh
AU - Okazaki, Mikio
AU - Sugimoto, Seiichiro
AU - Yamane, Masaomi
AU - Toyooka, Shinichi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research [20K09176] from the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to The Japanese Association for Thoracic Surgery.
PY - 2022
Y1 - 2022
N2 - Objective: The prognostic nutrition index (PNI), calculated using serum albumin and total lymphocyte count, is a recent topical index related to inflammation. Preoperative PNI is regarded as a new preoperative prognostic score in lung transplantation (LTx). This study aimed to investigate the impact of PNI at the time of registration as a prognostic parameter of mortality on the waiting list for LTx. Methods: A retrospective review was conducted on the data of 132 adult patients registered for LTx in our department between January 2013 and June 2020. Patients who finally received LTx were analyzed as censored data. The overall survival was evaluated using the Kaplan–Meier method for pre-registered clinical factors including the PNI at the time of registration. Overall survival was calculated from the date of listing to the Japan Organ Transplant Network to the date of death. Results: The low-PNI group had a significantly worse prognosis. Multivariate analysis demonstrated that age (p = 0.023), idiopathic interstitial pneumonia (p < 0.001), lung allocation score (LAS) (p < 0.001), and PNI (p < 0.001) were independent prognostic factors for waitlist mortality. Conclusions: PNI at the time of registration can be an independent prognostic parameter in registered candidates for LTx.
AB - Objective: The prognostic nutrition index (PNI), calculated using serum albumin and total lymphocyte count, is a recent topical index related to inflammation. Preoperative PNI is regarded as a new preoperative prognostic score in lung transplantation (LTx). This study aimed to investigate the impact of PNI at the time of registration as a prognostic parameter of mortality on the waiting list for LTx. Methods: A retrospective review was conducted on the data of 132 adult patients registered for LTx in our department between January 2013 and June 2020. Patients who finally received LTx were analyzed as censored data. The overall survival was evaluated using the Kaplan–Meier method for pre-registered clinical factors including the PNI at the time of registration. Overall survival was calculated from the date of listing to the Japan Organ Transplant Network to the date of death. Results: The low-PNI group had a significantly worse prognosis. Multivariate analysis demonstrated that age (p = 0.023), idiopathic interstitial pneumonia (p < 0.001), lung allocation score (LAS) (p < 0.001), and PNI (p < 0.001) were independent prognostic factors for waitlist mortality. Conclusions: PNI at the time of registration can be an independent prognostic parameter in registered candidates for LTx.
KW - Lung allocation score
KW - Lung transplantation
KW - Prognostic nutrition index
KW - Waitlist mortality
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U2 - 10.1007/s11748-022-01895-3
DO - 10.1007/s11748-022-01895-3
M3 - Article
C2 - 36495468
AN - SCOPUS:85143607030
SN - 1863-6705
JO - General Thoracic and Cardiovascular Surgery
JF - General Thoracic and Cardiovascular Surgery
ER -