The manzamine alkaloids

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Citations (Scopus)


The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A–C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine alkaloids are a unique class of alkaloids possessing a characteristic heterocyclic system, and exhibit a diverse range of bioactivities including cytotoxicity, antimicrobial activity, antimalarial activity, antiviral and antiinflammatory activities, antiinsecticidal activity, and proteasome inhibitory activity. About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 5 families. The unusual ring systems, an intriguing suggested biogenetic pathway, and promising biological activities of manzamine alkaloids have attracted great interest as challenging targets for the total synthesis. This review is the continuation of the previous review published in volume 60 of The Alkaloids and covers isolation, structure elucidation, biosynthesis and biogenesis, chemical synthesis, and biological activity of manzamine alkaloids reported from 2003 to 2018.

Original languageEnglish
Title of host publicationThe Alkaloids
EditorsHans-Joachim Knölker
PublisherAcademic Press Inc.
Number of pages124
ISBN (Print)9780128209820
Publication statusPublished - 2020
Externally publishedYes

Publication series

NameAlkaloids: Chemistry and Biology
ISSN (Print)1099-4831


  • Biological activity
  • Biosynthesis
  • Isolation
  • Manzamine
  • Marine natural product
  • Marine sponge
  • Structure elucidation
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry


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