The mechanisms of the development of atherosclerosis in prediabetes

Yin Liang; Mengxue Wang; Chen Wang; Yun Liu; Keiji Naruse; Ken Takahashi

doi:10.3390/ijms22084108

The mechanisms of the development of atherosclerosis in prediabetes

Yin Liang, Mengxue Wang, Chen Wang, Yun Liu, Keiji Naruse, Ken Takahashi

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Lifestyle changes, such as overeating and underexercising, can increase the risk of predi-abetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addi-tion to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.

Original language	English
Article number	4108
Journal	International journal of molecular sciences
Volume	22
Issue number	8
DOIs	https://doi.org/10.3390/ijms22084108
Publication status	Published - Apr 2 2021

Keywords

Atherosclerosis
Endothelial dysfunction
Exosome
Metabolic syndrome
MicroRNA
Obesity
Prediabetes

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms22084108

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title = "The mechanisms of the development of atherosclerosis in prediabetes",

abstract = "Lifestyle changes, such as overeating and underexercising, can increase the risk of predi-abetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addi-tion to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.",

keywords = "Atherosclerosis, Endothelial dysfunction, Exosome, Metabolic syndrome, MicroRNA, Obesity, Prediabetes",

author = "Yin Liang and Mengxue Wang and Chen Wang and Yun Liu and Keiji Naruse and Ken Takahashi",

note = "Funding Information: Funding: This study was funded by JSPS KAKENHI, Fund for the Promotion of Joint International Research (Fostering Joint International Research), 17KK0168, and JSPS KAKENHI Grant‐In‐Aid for Scientific Research (B), 20H04518. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/ijms22084108",

language = "English",

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T1 - The mechanisms of the development of atherosclerosis in prediabetes

AU - Liang, Yin

AU - Wang, Mengxue

AU - Wang, Chen

AU - Liu, Yun

AU - Naruse, Keiji

AU - Takahashi, Ken

N1 - Funding Information: Funding: This study was funded by JSPS KAKENHI, Fund for the Promotion of Joint International Research (Fostering Joint International Research), 17KK0168, and JSPS KAKENHI Grant‐In‐Aid for Scientific Research (B), 20H04518. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/4/2

Y1 - 2021/4/2

N2 - Lifestyle changes, such as overeating and underexercising, can increase the risk of predi-abetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addi-tion to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.

AB - Lifestyle changes, such as overeating and underexercising, can increase the risk of predi-abetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addi-tion to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.

KW - Atherosclerosis

KW - Endothelial dysfunction

KW - Exosome

KW - Metabolic syndrome

KW - MicroRNA

KW - Obesity

KW - Prediabetes

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U2 - 10.3390/ijms22084108

DO - 10.3390/ijms22084108

M3 - Review article

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SN - 1661-6596

VL - 22

JO - International journal of molecular sciences

JF - International journal of molecular sciences

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ER -

The mechanisms of the development of atherosclerosis in prediabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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