Abstract
Lifestyle changes, such as overeating and underexercising, can increase the risk of predi-abetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addi-tion to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.
| Original language | English |
|---|---|
| Article number | 4108 |
| Journal | International journal of molecular sciences |
| Volume | 22 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Apr 2 2021 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Atherosclerosis
- Endothelial dysfunction
- Exosome
- Metabolic syndrome
- MicroRNA
- Obesity
- Prediabetes
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Computer Science Applications
- Spectroscopy
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
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