TY - JOUR
T1 - The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas
AU - Yamamoto, Hiromasa
AU - Namba, Kei
AU - Yamamoto, Haruchika
AU - Toji, Tomohiro
AU - Sou, Junichi
AU - Shien, Kazuhiko
AU - Suzawa, Ken
AU - Kurosaki, Takeshi
AU - Otani, Shinji
AU - Okazaki, Mikio
AU - Sugimoto, Seiichiro
AU - Yamane, Masaomi
AU - Takahashi, Katsuhito
AU - Kunisada, Toshiyuki
AU - Oto, Takahiro
AU - Toyooka, Shinichi
N1 - Funding Information:
We thank Ms. Fumiko Isobe of the Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, for her technical assistance.
Publisher Copyright:
© 2020, Springer Nature Singapore Pte Ltd.
PY - 2021/1
Y1 - 2021/1
N2 - Purpose: Sarcomas are among the most refractory malignant tumors and often recur as pulmonary metastasis. Although the presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with the prognosis of several malignancies, the relationship between the NLR and sarcoma with pulmonary metastasis is unclear. We investigated the impact of the NLR in patients who underwent surgical resection for metastatic lung tumors from various sarcomas. Methods: The subjects of this retrospective study were 158 patients with metastatic lung tumors from various sarcomas, who underwent initial pulmonary metastasectomy between 2006 and 2015. We examined the clinicopathological variables, including the NLR and the characteristics of surgical procedures. Survival was estimated by the Kaplan–Meier method and prognostic factors were evaluated by multivariate analysis. Results: Multivariate analysis revealed significantly better survival of the group with an NLR < 2.26 immediately before the most recent pulmonary metastasectomy, in addition to such factors as the largest resected lesion being < 22 mm, a disease-free interval of > 2 years, and 3 or more pulmonary metastasectomies. Conclusion: The NLR immediately before the most recent pulmonary metastasectomy is a novel independent prognostic factor, which may be helpful when considering repeated pulmonary metastasectomy.
AB - Purpose: Sarcomas are among the most refractory malignant tumors and often recur as pulmonary metastasis. Although the presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with the prognosis of several malignancies, the relationship between the NLR and sarcoma with pulmonary metastasis is unclear. We investigated the impact of the NLR in patients who underwent surgical resection for metastatic lung tumors from various sarcomas. Methods: The subjects of this retrospective study were 158 patients with metastatic lung tumors from various sarcomas, who underwent initial pulmonary metastasectomy between 2006 and 2015. We examined the clinicopathological variables, including the NLR and the characteristics of surgical procedures. Survival was estimated by the Kaplan–Meier method and prognostic factors were evaluated by multivariate analysis. Results: Multivariate analysis revealed significantly better survival of the group with an NLR < 2.26 immediately before the most recent pulmonary metastasectomy, in addition to such factors as the largest resected lesion being < 22 mm, a disease-free interval of > 2 years, and 3 or more pulmonary metastasectomies. Conclusion: The NLR immediately before the most recent pulmonary metastasectomy is a novel independent prognostic factor, which may be helpful when considering repeated pulmonary metastasectomy.
KW - Metastasectomy
KW - Metastatic lung tumor
KW - Neutrophil-to-lymphocyte ratio (NLR)
KW - Sarcoma
KW - Survival rate
UR - http://www.scopus.com/inward/record.url?scp=85088855620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088855620&partnerID=8YFLogxK
U2 - 10.1007/s00595-020-02093-5
DO - 10.1007/s00595-020-02093-5
M3 - Article
C2 - 32747982
AN - SCOPUS:85088855620
SN - 0941-1291
VL - 51
SP - 127
EP - 135
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
IS - 1
ER -