The prognosis of elderly patients with aortic stenosis after transcatheter aortic valve replacement

Yukihiro Saito, Erik E. Lewis, Amish Raval, Giorgio Gimelli, Kurt M. Jacobson, Satoru Osaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective Aortic stenosis (AS) is common among elderly patients. Since transcatheter aortic valve replacement (TAVR) is a less invasive procedure than surgical aortic valve replacement for symptomatic severe AS, super-elderly patients have tended to undergo TAVR. We retrospectively investigated the post-TAVR outcome in super-elderly patients with severe AS. Methods This analysis included 433 patients who underwent TAVR in the University of Wisconsin Hospital and Clinics from 2012 to 2017. Post-TAVR mortality, complications in-hospital, rehospitalization, the New York Heart Association (NYHA) functional class and echocardiographic parameters were compared between patients <85 years old (n = 290) and _85 years old (n = 143). Results The patients _85 years old less frequently had a history of coronary artery disease (73.1% vs. 62.2%, p=0.026) and hypertension (87.2% vs. 77.6%, p=0.012) than younger patients. Furthermore, the patients _85 years old had moderate-severe mitral regurgitation more frequently (19.3% vs. 28.7%, p=0.037) at baseline than younger patients. There was no significant difference in in-hospital outcomes between the age groups. The 30-day mortality was worse in patients _85 years old than in younger ones (0.7% vs. 3.5%, p= 0.042). While there was no significant difference in the long-term mortality between the 2 groups, the estimated 1-year mortality from Kaplan-Meier curves were 9.6% in patients <85 years old and 14.9% in patients _85 years old. The rate of in-hospital complications, rehospitalization rate, improvement in the NYHA functional class and echocardiographic parameters were comparable between the two groups. Conclusion The outcomes of super-elderly patients after TAVR were acceptable, suggesting that these patients could benefit from TAVR.

Original languageEnglish
Pages (from-to)517-523
Number of pages7
JournalInternal Medicine
Issue number4
Publication statusPublished - Feb 15 2021
Externally publishedYes


  • Severe AS
  • TAVR

ASJC Scopus subject areas

  • Internal Medicine


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