The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka; M. Suzuki; R. Maruyama; K. O. Toyooka; Kazunori Tsukuda; Y. Fukuyama; T. Iizasa; M. Aoe; H. Date; T. Fujisawa; N. Shimizu; A. F. Gazdar

doi:10.1038/sj.bjc.6602013

The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka, M. Suzuki, R. Maruyama, K. O. Toyooka, Kazunori Tsukuda, Y. Fukuyama, T. Iizasa, M. Aoe, H. Date, T. Fujisawa, N. Shimizu, A. F. Gazdar

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

The present study examined the relationship between methylation of five genes (p16^INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16^INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

Original language	English
Pages (from-to)	771-774
Number of pages	4
Journal	British Journal of Cancer
Volume	91
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6602013
Publication status	Published - Aug 16 2004

Keywords

Adenocarcinoma of lung
Methylation
Non-small-cell lung cancer
p16

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6602013

Cite this

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AU - Tsukuda, Kazunori

AU - Fukuyama, Y.

AU - Iizasa, T.

AU - Aoe, M.

AU - Date, H.

AU - Fujisawa, T.

AU - Shimizu, N.

AU - Gazdar, A. F.

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AB - The present study examined the relationship between methylation of five genes (p16INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

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The relationship between aberrant methylation and survival in non-small-cell lung cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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