The role of caveolin-1 in prostate cancer: Clinical implications

T. C. Thompson; S. A. Tahir; L. Li; M. Watanabe; K. Naruishi; G. Yang; D. Kadmon; C. J. Logothetis; P. Troncoso; C. Ren; A. Goltsov; S. Park

doi:10.1038/pcan.2009.29

The role of caveolin-1 in prostate cancer: Clinical implications

T. C. Thompson, S. A. Tahir, L. Li, M. Watanabe, K. Naruishi, G. Yang, D. Kadmon, C. J. Logothetis, P. Troncoso, C. Ren, A. Goltsov, S. Park

University Hospital

Research output: Contribution to journal › Review article › peer-review

79 Citations (Scopus)

Abstract

Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.

Original language	English
Pages (from-to)	6-11
Number of pages	6
Journal	Prostate Cancer and Prostatic Diseases
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/pcan.2009.29
Publication status	Published - Mar 2010

Keywords

Angiogenesis
Biomarkers
Caveolin-1
Progression

ASJC Scopus subject areas

Oncology
Urology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/pcan.2009.29

Cite this

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title = "The role of caveolin-1 in prostate cancer: Clinical implications",

abstract = "Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.",

keywords = "Angiogenesis, Biomarkers, Caveolin-1, Progression",

author = "Thompson, {T. C.} and Tahir, {S. A.} and L. Li and M. Watanabe and K. Naruishi and G. Yang and D. Kadmon and Logothetis, {C. J.} and P. Troncoso and C. Ren and A. Goltsov and S. Park",

note = "Funding Information: This work was supported in part by NIH R01 CA68814 and Department of Defense Grant DAMD PC051247.",

year = "2010",

month = mar,

doi = "10.1038/pcan.2009.29",

language = "English",

volume = "13",

pages = "6--11",

journal = "Prostate Cancer and Prostatic Diseases",

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T1 - The role of caveolin-1 in prostate cancer

T2 - Clinical implications

AU - Thompson, T. C.

AU - Tahir, S. A.

AU - Li, L.

AU - Watanabe, M.

AU - Naruishi, K.

AU - Yang, G.

AU - Kadmon, D.

AU - Logothetis, C. J.

AU - Troncoso, P.

AU - Ren, C.

AU - Goltsov, A.

AU - Park, S.

N1 - Funding Information: This work was supported in part by NIH R01 CA68814 and Department of Defense Grant DAMD PC051247.

PY - 2010/3

Y1 - 2010/3

N2 - Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.

AB - Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.

KW - Angiogenesis

KW - Biomarkers

KW - Caveolin-1

KW - Progression

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DO - 10.1038/pcan.2009.29

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SN - 1365-7852

VL - 13

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JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

IS - 1

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The role of caveolin-1 in prostate cancer: Clinical implications

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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