The role of glucan-binding proteins in the cariogenicity of Streptococcus mutans

Mieko Matsumura; Tomohiro Izumi; Michiyo Matsumoto; Masato Tsuji; Taku Fujiwara; Takashi Ooshima

doi:10.1111/j.1348-0421.2003.tb03389.x

The role of glucan-binding proteins in the cariogenicity of Streptococcus mutans

Mieko Matsumura, Tomohiro Izumi, Michiyo Matsumoto, Masato Tsuji, Taku Fujiwara, Takashi Ooshima

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Streptococcus mutans produces glucan-binding proteins (Gbps), which appear to contribute to the virulence of S. mutans. GbpA and GbpC genes were inactivated by the insertion of antibiotic-resistant genes into each gbp gene of S. mutans MT8148 to generate Gbp-defective mutants. Sucrose dependent adherences of the GbpA- and GbpC-defective mutants were found to be significantly lower than those of their parent strains MT8148. Caries inducing activity of the mutants in rats was significantly lower than that of strain MT8148R (streptomycin-resistant strain of MT8148). These results suggest that GbpA and GbpC participate in cellular adherence to tooth surfaces and contribute to the cariogenicity of S. mutans.

Original language	English
Pages (from-to)	213-215
Number of pages	3
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	47
Issue number	3
DOIs	https://doi.org/10.1111/j.1348-0421.2003.tb03389.x
Publication status	Published - 2003
Externally published	Yes

Keywords

Cariogenicity
Glucan-binding protein
Isogenic mutant
Streptococcus mutans

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/j.1348-0421.2003.tb03389.x

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abstract = "Streptococcus mutans produces glucan-binding proteins (Gbps), which appear to contribute to the virulence of S. mutans. GbpA and GbpC genes were inactivated by the insertion of antibiotic-resistant genes into each gbp gene of S. mutans MT8148 to generate Gbp-defective mutants. Sucrose dependent adherences of the GbpA- and GbpC-defective mutants were found to be significantly lower than those of their parent strains MT8148. Caries inducing activity of the mutants in rats was significantly lower than that of strain MT8148R (streptomycin-resistant strain of MT8148). These results suggest that GbpA and GbpC participate in cellular adherence to tooth surfaces and contribute to the cariogenicity of S. mutans.",

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AU - Matsumura, Mieko

AU - Izumi, Tomohiro

AU - Matsumoto, Michiyo

AU - Tsuji, Masato

AU - Fujiwara, Taku

AU - Ooshima, Takashi

PY - 2003

Y1 - 2003

N2 - Streptococcus mutans produces glucan-binding proteins (Gbps), which appear to contribute to the virulence of S. mutans. GbpA and GbpC genes were inactivated by the insertion of antibiotic-resistant genes into each gbp gene of S. mutans MT8148 to generate Gbp-defective mutants. Sucrose dependent adherences of the GbpA- and GbpC-defective mutants were found to be significantly lower than those of their parent strains MT8148. Caries inducing activity of the mutants in rats was significantly lower than that of strain MT8148R (streptomycin-resistant strain of MT8148). These results suggest that GbpA and GbpC participate in cellular adherence to tooth surfaces and contribute to the cariogenicity of S. mutans.

AB - Streptococcus mutans produces glucan-binding proteins (Gbps), which appear to contribute to the virulence of S. mutans. GbpA and GbpC genes were inactivated by the insertion of antibiotic-resistant genes into each gbp gene of S. mutans MT8148 to generate Gbp-defective mutants. Sucrose dependent adherences of the GbpA- and GbpC-defective mutants were found to be significantly lower than those of their parent strains MT8148. Caries inducing activity of the mutants in rats was significantly lower than that of strain MT8148R (streptomycin-resistant strain of MT8148). These results suggest that GbpA and GbpC participate in cellular adherence to tooth surfaces and contribute to the cariogenicity of S. mutans.

KW - Cariogenicity

KW - Glucan-binding protein

KW - Isogenic mutant

KW - Streptococcus mutans

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The role of glucan-binding proteins in the cariogenicity of Streptococcus mutans

Abstract

Keywords

ASJC Scopus subject areas

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