The role of interleukin-8 in interstitial pneumonia

Yoshiaki Fujimori, Mikio Kataoka, Shinya Tada, Hideki Takehara, Kiyoshi Matsuo, Toshitsugu Miyake, Masayuki Okahara, Ichiro Yamadori, Mitsune Tanimoto

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Objective: A variety of inflammatory cells accumulate in the lungs of patients with interstitial lung disease. The potential for IL-8 to be released from these cells into the lungs of patients with idiopathic interstitial pneumonia (IIP), interstitial pneumonia with collagen vascular disease (IP-CVD), sarcoidosis (SAR) and hypersensitivity pneumonitis (HP) was investigated. Methodology: IL-8 levels were assessed by enzyme-linked immunosorbent assay in BAL fluid and serum, and the expression of IL-8 in the lungs of these patients was evaluated by immunohistochemistry. Results: Serum IL-8 levels were significantly elevated in patients with IIP (P < 0.05) and SAR (P < 0.01). In BAL fluid, the IL-8 level was significantly higher in patients with IIP (P < 0.05), IP-CVD (P < 0.01), SAR (P < 0.01) and HP (P < 0.01). In several cases, IL-8 level correlated with neutrophil density. The IL-8 immunopositive cells were type II pulmonary epithelial cells and alveolar and interstitial macrophages in patients with IIP and IP-CVD. Conclusions: IL-8 is likely to be a key factor in the pathogenesis of fibrosis of the lung and in lung injury.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
Issue number1
Publication statusPublished - Mar 2003


  • Bronchoalveolar lavage
  • Collagen vascular disease
  • Idiopathic interstitial pneumonia
  • Immunohistochemical staining
  • Interleukin-8
  • Non-specific interstitial pneumonia
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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