The surface property of hydroxyapatite: Sensing with quartz crystal microbalance

T. Ikoma, M. Tagaya, T. Tonegawa, M. Okuda, N. Hanagata, T. Yoshioka, D. Chakarov, B. Kasemo, J. Tanaka

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Hydroxyapatite (HAp) sensor, available for quartz crystal microbalance with dissipation (QCM-D) technique, has been fabricated by an electrophoretic deposition method. The method of re-usability of the sensor after adsorption of fibrinogen and the biological apatite (BAp) growth on the sensor with and without the adsorption of feral bovine serum (FBS) from 1.5 simulated body fluid were investigated. The re-usability of the sensor, cleaning with the combination of ammonia and hydrogen peroxide mixture and UV/ozone treatment, achieved ten times reuses. BAp was grown on the HAp surface but not on the gold surface at 37.5 °C for 40 hours. The viscoelastic property (ΔD/Δf value) of the BAp layer on the HAp sensor showed harder than that of the protein adsorption films from FBS. The amount of the BAp grown on the HAp sensor adsorbed FBS is lower than that on the HAp sensor. The adsorption of FBS proteins on the HAp surface strongly inhibited the BAp growth.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2009
Externally publishedYes


  • Biosensor
  • Hydroxyapatite (HAp)
  • QCM-D
  • Simulated body fluid (SBF)

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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