The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences

Akira Shimada; Shunsuke Kato; Kentaro Enjo; Motonobu Osada; Yoji Ikawa; Kenji Kohno; Masuo Obinata; Ryunosuke Kanamaru; Shuntaro Ikawa; Chikashi Ishioka

The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences

Akira Shimada, Shunsuke Kato, Kentaro Enjo, Motonobu Osada, Yoji Ikawa, Kenji Kohno, Masuo Obinata, Ryunosuke Kanamaru, Shuntaro Ikawa, Chikashi Ishioka

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharomyces cerevisiae and mammalian cells and used them to investigate the functional similarities and differences of these genes. We found that p51/p63 trans-activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53. These results suggest that the cellular signal on p51/p63 cross- talks partially but not completely with that of the p53 pathway.

Original language	English
Pages (from-to)	2781-2786
Number of pages	6
Journal	Cancer Research
Volume	59
Issue number	12
Publication status	Published - Jun 15 1999
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{e5b2ac654f624f5088bb7d6a24e7d35b,

title = "The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences",

abstract = "p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharomyces cerevisiae and mammalian cells and used them to investigate the functional similarities and differences of these genes. We found that p51/p63 trans-activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53. These results suggest that the cellular signal on p51/p63 cross- talks partially but not completely with that of the p53 pathway.",

author = "Akira Shimada and Shunsuke Kato and Kentaro Enjo and Motonobu Osada and Yoji Ikawa and Kenji Kohno and Masuo Obinata and Ryunosuke Kanamaru and Shuntaro Ikawa and Chikashi Ishioka",

year = "1999",

month = jun,

day = "15",

language = "English",

volume = "59",

pages = "2781--2786",

journal = "Cancer Research",

issn = "0008-5472",

number = "12",

}

TY - JOUR

T1 - The transcriptional activities of p53 and its homologue p51/p63

T2 - Similarities and differences

AU - Shimada, Akira

AU - Kato, Shunsuke

AU - Enjo, Kentaro

AU - Osada, Motonobu

AU - Ikawa, Yoji

AU - Kohno, Kenji

AU - Obinata, Masuo

AU - Kanamaru, Ryunosuke

AU - Ikawa, Shuntaro

AU - Ishioka, Chikashi

PY - 1999/6/15

Y1 - 1999/6/15

N2 - p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharomyces cerevisiae and mammalian cells and used them to investigate the functional similarities and differences of these genes. We found that p51/p63 trans-activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53. These results suggest that the cellular signal on p51/p63 cross- talks partially but not completely with that of the p53 pathway.

AB - p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharomyces cerevisiae and mammalian cells and used them to investigate the functional similarities and differences of these genes. We found that p51/p63 trans-activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53. These results suggest that the cellular signal on p51/p63 cross- talks partially but not completely with that of the p53 pathway.

UR - http://www.scopus.com/inward/record.url?scp=0033564131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033564131&partnerID=8YFLogxK

M3 - Article

C2 - 10383130

AN - SCOPUS:0033564131

SN - 0008-5472

VL - 59

SP - 2781

EP - 2786

JO - Cancer Research

JF - Cancer Research

IS - 12

ER -

The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences

Abstract

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this