TY - JOUR
T1 - The usefulness of pre-radiofrequency ablation SUV max in 18F-FDG PET/CT to predict the risk of a local recurrence of malignant lung tumors after lung radiofrequency ablation
AU - Harada, Sosuke
AU - Sato, Shuhei
AU - Suzuki, Etsuji
AU - Okumura, Yoshihiro
AU - Hiraki, Takao
AU - Gobara, Hideo
AU - Mimura, Hidefumi
AU - Kanazawa, Susumu
AU - Kaji, Mitsumasa
AU - Fujiwara, Toshiyoshi
PY - 2011/12/22
Y1 - 2011/12/22
N2 - The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose ( 18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUV max). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUV max. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUV max and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUV max showed higher recurrence odds ratios (medium group; 1.84, high group; 4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67); we thought this was mainly due to selection bias because we excluded tumors less than 10 mm in diameter. This study demonstrated the pre-RFA SUV max in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors.
AB - The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose ( 18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUV max). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUV max. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUV max and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUV max showed higher recurrence odds ratios (medium group; 1.84, high group; 4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67); we thought this was mainly due to selection bias because we excluded tumors less than 10 mm in diameter. This study demonstrated the pre-RFA SUV max in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors.
KW - Fluorodeoxyglucose (FDG)
KW - Lung
KW - Positron emission tomography (PET)
KW - Radiofrequency ablation (RFA)
KW - Standardized uptake value (SUV)
UR - http://www.scopus.com/inward/record.url?scp=84858204238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858204238&partnerID=8YFLogxK
M3 - Article
C2 - 22189480
AN - SCOPUS:84858204238
SN - 0386-300X
VL - 65
SP - 395
EP - 402
JO - Acta medica Okayama
JF - Acta medica Okayama
IS - 6
ER -