Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke

Naoki Tajiri, Sandra Acosta, Gabriel S. Portillo-Gonzales, Daniela Aguirre, Stephanny Reyes, Diego Lozano, Mibel Pabon, Ike Dela Peña, Xunming Ji, Takao Yasuhara, Isao Date, Marianna A. Solomita, Ivana Antonucci, Liborio Stuppia, Yuji Kaneko, Cesar V. Borlongan

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Accumulating preclinical evidence suggests the use of amnion as a source of stem cells for investigations of basic science concepts related to developmental cell biology, but also for stem cells' therapeutic applications in treating human disorders. We previously reported isolation of viable rat amniotic fluid-derived stem (AFS) cells. Subsequently, we recently reported the therapeutic benefits of intravenous transplantation of AFS cells in a rodent model of ischemic stroke. Parallel lines of investigations have provided safety and efficacy of stem cell therapy for treating stroke and other neurological disorders. This review article highlights the need for investigations of mechanisms underlying AFS cells' therapeutic benefits and discusses lab-to-clinic translational gating items in an effort to optimize the clinical application of the cell transplantation for stroke.

Original languageEnglish
Article number227
JournalFrontiers in Cellular Neuroscience
Issue numberAUG
Publication statusPublished - Aug 13 2014


  • Cerebral ischemia
  • Neural stem/progenitor cells
  • Neurogenesis
  • Neurotrophic factors
  • Regenerative medicine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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