Thermochemotherapy of a human salivary adenocarcinoma cell line

Jun Ichi Asaumi; Yuzuru Higuchi; Hidenobu Matsuzaki; Jun Murakami; Shoji Kawasaki; Masahiro Kuroda; Koichi Shibuya; Hironobu Konouchi; Miki Hisatomi; Toru Wakasa; Kanji Kishi; Yoshio Hiraki

doi:10.3892/or.9.2.365

Thermochemotherapy of a human salivary adenocarcinoma cell line

Jun Ichi Asaumi, Yuzuru Higuchi, Hidenobu Matsuzaki, Jun Murakami, Shoji Kawasaki, Masahiro Kuroda, Koichi Shibuya, Hironobu Konouchi, Miki Hisatomi, Toru Wakasa, Kanji Kishi, Yoshio Hiraki

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43°C for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41°C in adriamycin, 42°C in cisplatin, 37°C in mitomycin C, and 42°C in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.

Original language	English
Pages (from-to)	365-369
Number of pages	5
Journal	Oncology reports
Volume	9
Issue number	2
DOIs	https://doi.org/10.3892/or.9.2.365
Publication status	Published - Mar 2002

Keywords

Adenocarcinoma
Oral cancer
Salivary gland tumor
Thermochemotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or.9.2.365

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title = "Thermochemotherapy of a human salivary adenocarcinoma cell line",

abstract = "We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43°C for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41°C in adriamycin, 42°C in cisplatin, 37°C in mitomycin C, and 42°C in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.",

keywords = "Adenocarcinoma, Oral cancer, Salivary gland tumor, Thermochemotherapy",

author = "Asaumi, {Jun Ichi} and Yuzuru Higuchi and Hidenobu Matsuzaki and Jun Murakami and Shoji Kawasaki and Masahiro Kuroda and Koichi Shibuya and Hironobu Konouchi and Miki Hisatomi and Toru Wakasa and Kanji Kishi and Yoshio Hiraki",

year = "2002",

month = mar,

doi = "10.3892/or.9.2.365",

language = "English",

volume = "9",

pages = "365--369",

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T1 - Thermochemotherapy of a human salivary adenocarcinoma cell line

AU - Asaumi, Jun Ichi

AU - Higuchi, Yuzuru

AU - Matsuzaki, Hidenobu

AU - Murakami, Jun

AU - Kawasaki, Shoji

AU - Kuroda, Masahiro

AU - Shibuya, Koichi

AU - Konouchi, Hironobu

AU - Hisatomi, Miki

AU - Wakasa, Toru

AU - Kishi, Kanji

AU - Hiraki, Yoshio

PY - 2002/3

Y1 - 2002/3

N2 - We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43°C for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41°C in adriamycin, 42°C in cisplatin, 37°C in mitomycin C, and 42°C in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.

AB - We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43°C for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41°C in adriamycin, 42°C in cisplatin, 37°C in mitomycin C, and 42°C in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.

KW - Adenocarcinoma

KW - Oral cancer

KW - Salivary gland tumor

KW - Thermochemotherapy

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DO - 10.3892/or.9.2.365

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EP - 369

JO - Oncology reports

JF - Oncology reports

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ER -

Thermochemotherapy of a human salivary adenocarcinoma cell line

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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