Three-dimensional architecture of glomerular extracellular matrices in diabetic glomerulosclerosis

Hirofumi Makino; Shigeaki Nishimura; Toshinori Haramoto; Yasushi Yamasaki; Shuji Ikeda; Zensuke Ota

doi:10.1016/0891-6632(91)90041-M

Three-dimensional architecture of glomerular extracellular matrices in diabetic glomerulosclerosis

Hirofumi Makino, Shigeaki Nishimura, Toshinori Haramoto, Yasushi Yamasaki, Shuji Ikeda, Zensuke Ota

Research output: Contribution to journal › Article › peer-review

Abstract

The three-dimensional ultrastructural changes of the glomerular extracellular matrices in diabetic glomerulosclerosis were studied in acellular rat and human diabetic glomeruli by scanning electron microscopy. The mesangial matrix appeared as fenestrated septa with oval stomata between the glomerular capillaries in normal control specimens. In diabetic glomerulosclerosis, both in humans and rats, expansion of mesangial matrix and narrowing of the mesangial fenestrae were observed. A thin layer of the mesangial matrix extended into the peripheral glomerular basement membrane (GBM) subendothelially. Thickening of the GBM in diabetic nephropathy might be due to expansion of the mesangial matrix into the peripheral GBM.

Original language	English
Pages (from-to)	124-125
Number of pages	2
Journal	Journal of Diabetic Complications
Volume	5
Issue number	2-3
DOIs	https://doi.org/10.1016/0891-6632(91)90041-M
Publication status	Published - 1991

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0891-6632(91)90041-M

Cite this

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title = "Three-dimensional architecture of glomerular extracellular matrices in diabetic glomerulosclerosis",

abstract = "The three-dimensional ultrastructural changes of the glomerular extracellular matrices in diabetic glomerulosclerosis were studied in acellular rat and human diabetic glomeruli by scanning electron microscopy. The mesangial matrix appeared as fenestrated septa with oval stomata between the glomerular capillaries in normal control specimens. In diabetic glomerulosclerosis, both in humans and rats, expansion of mesangial matrix and narrowing of the mesangial fenestrae were observed. A thin layer of the mesangial matrix extended into the peripheral glomerular basement membrane (GBM) subendothelially. Thickening of the GBM in diabetic nephropathy might be due to expansion of the mesangial matrix into the peripheral GBM.",

author = "Hirofumi Makino and Shigeaki Nishimura and Toshinori Haramoto and Yasushi Yamasaki and Shuji Ikeda and Zensuke Ota",

note = "Funding Information: This research was supported by a Grant-in-Aid for Scientific Research (C-01570644)t o Dr. Hirofumi Makino from the Ministry of Education, Science and Culture.",

year = "1991",

doi = "10.1016/0891-6632(91)90041-M",

language = "English",

volume = "5",

pages = "124--125",

journal = "Journal of Diabetes and its Complications",

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publisher = "Elsevier Inc.",

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T1 - Three-dimensional architecture of glomerular extracellular matrices in diabetic glomerulosclerosis

AU - Makino, Hirofumi

AU - Nishimura, Shigeaki

AU - Haramoto, Toshinori

AU - Yamasaki, Yasushi

AU - Ikeda, Shuji

AU - Ota, Zensuke

N1 - Funding Information: This research was supported by a Grant-in-Aid for Scientific Research (C-01570644)t o Dr. Hirofumi Makino from the Ministry of Education, Science and Culture.

PY - 1991

Y1 - 1991

N2 - The three-dimensional ultrastructural changes of the glomerular extracellular matrices in diabetic glomerulosclerosis were studied in acellular rat and human diabetic glomeruli by scanning electron microscopy. The mesangial matrix appeared as fenestrated septa with oval stomata between the glomerular capillaries in normal control specimens. In diabetic glomerulosclerosis, both in humans and rats, expansion of mesangial matrix and narrowing of the mesangial fenestrae were observed. A thin layer of the mesangial matrix extended into the peripheral glomerular basement membrane (GBM) subendothelially. Thickening of the GBM in diabetic nephropathy might be due to expansion of the mesangial matrix into the peripheral GBM.

AB - The three-dimensional ultrastructural changes of the glomerular extracellular matrices in diabetic glomerulosclerosis were studied in acellular rat and human diabetic glomeruli by scanning electron microscopy. The mesangial matrix appeared as fenestrated septa with oval stomata between the glomerular capillaries in normal control specimens. In diabetic glomerulosclerosis, both in humans and rats, expansion of mesangial matrix and narrowing of the mesangial fenestrae were observed. A thin layer of the mesangial matrix extended into the peripheral glomerular basement membrane (GBM) subendothelially. Thickening of the GBM in diabetic nephropathy might be due to expansion of the mesangial matrix into the peripheral GBM.

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JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 2-3

ER -

Three-dimensional architecture of glomerular extracellular matrices in diabetic glomerulosclerosis

Abstract

ASJC Scopus subject areas

UN SDGs

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