TY - JOUR
T1 - Three new flavonoids, proanthocyanidin, and accompanying phenolic constituents from Feijoa sellowiana
AU - Aoyama, Hiroe
AU - Sakagami, Hiroshi
AU - Hatano, Tsutomu
N1 - Funding Information:
This work was supported by a Grant-in-Aid from JSPS [grant number 25450170].
Publisher Copyright:
© 2017 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2018
Y1 - 2018
N2 - Our investigation of phenolic constituents of fruits, flower buds, and leaves of Feijoa sellowiana led to the isolation of twenty-one phenolics including three new gossypetin glycosides 1-3, and also the purification of a proanthocyanidin fraction. A high-performance liquid chromatography method for simultaneous analysis of phenolic constituents was established and then used to investigate the phenolic profiles of the parts of the plant species, to show the presence of characteristic flavonoids and ellagic acid derivatives or ellagitannins in the extracts from fruits, flower buds, and leaves. The branch extract profile also suggested the presence of alkylated ellagic acids as characteristic constituents. Inhibitory effects of feijoa flavonoids on mushroom tyrosinase were seen, although in some cases this may have resulted from direct interaction with the enzyme. Cytotoxic effect of the proanthocyanidin fraction was also shown.
AB - Our investigation of phenolic constituents of fruits, flower buds, and leaves of Feijoa sellowiana led to the isolation of twenty-one phenolics including three new gossypetin glycosides 1-3, and also the purification of a proanthocyanidin fraction. A high-performance liquid chromatography method for simultaneous analysis of phenolic constituents was established and then used to investigate the phenolic profiles of the parts of the plant species, to show the presence of characteristic flavonoids and ellagic acid derivatives or ellagitannins in the extracts from fruits, flower buds, and leaves. The branch extract profile also suggested the presence of alkylated ellagic acids as characteristic constituents. Inhibitory effects of feijoa flavonoids on mushroom tyrosinase were seen, although in some cases this may have resulted from direct interaction with the enzyme. Cytotoxic effect of the proanthocyanidin fraction was also shown.
KW - Cytotoxicity
KW - Feijoa sellowiana
KW - Flavonoid
KW - Myrtaceae
KW - Tyrosinase inhibitor
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U2 - 10.1080/09168451.2017.1412246
DO - 10.1080/09168451.2017.1412246
M3 - Article
C2 - 29297255
AN - SCOPUS:85040839022
SN - 0916-8451
VL - 82
SP - 31
EP - 40
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 1
ER -