Three type 6 hepatitis C virus subgroups among blood donors in the Yangon area of Myanmar are identified as subtypes 6m and 6n, and a novel subtype by sequence analysis of the core region

Toshiyuki Shinji; Aye Aye Lwin; Katsunori Gokan; Mikako Obika; Hiromasa Ryuko; Myo Khin; Shigeru Okada; Norio Koide

Three type 6 hepatitis C virus subgroups among blood donors in the Yangon area of Myanmar are identified as subtypes 6m and 6n, and a novel subtype by sequence analysis of the core region

Toshiyuki Shinji, Aye Aye Lwin, Katsunori Gokan, Mikako Obika, Hiromasa Ryuko, Myo Khin, Shigeru Okada, Norio Koide

Research output: Contribution to journal › Article › peer-review

Abstract

Previously, using phylogenetic analysis of NS5b sequences, we found that three type 6 variant subgroups (M6-1, M6-2 and M6-3) exist in Myanmar. According to the new nomenclature of hepatitis C, M6-1 and M6-2 belong to subtypes 6m and 6n, respectively, but M6-3 is unassigned. In this study, we sequenced and phylogenetically analyzed the core region of these type 6 variant subgroups. Serum samples assigned as 6m or 6n by NS5b sequence were also identified as 6 m or 6n by core region analysis. The M6-3 (sample name MYAN-3E-3) remained unassigned to a subgroup based on its core region analysis. The findings of this study suggest that either the core region or the NS5b region can be analyzed for HCV subtype classification. Copyright

Original language	English
Pages (from-to)	345-349
Number of pages	5
Journal	Acta medica Okayama
Volume	60
Issue number	6
Publication status	Published - Dec 2006

Keywords

HCV core
HCV genotype
Myanmar
Phylogenetic analysis
Type 6 subgroup

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Three type 6 hepatitis C virus subgroups among blood donors in the Yangon area of Myanmar are identified as subtypes 6m and 6n, and a novel subtype by sequence analysis of the core region. / Shinji, Toshiyuki; Lwin, Aye Aye; Gokan, Katsunori et al.
In: Acta medica Okayama, Vol. 60, No. 6, 12.2006, p. 345-349.

Research output: Contribution to journal › Article › peer-review

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title = "Three type 6 hepatitis C virus subgroups among blood donors in the Yangon area of Myanmar are identified as subtypes 6m and 6n, and a novel subtype by sequence analysis of the core region",

abstract = "Previously, using phylogenetic analysis of NS5b sequences, we found that three type 6 variant subgroups (M6-1, M6-2 and M6-3) exist in Myanmar. According to the new nomenclature of hepatitis C, M6-1 and M6-2 belong to subtypes 6m and 6n, respectively, but M6-3 is unassigned. In this study, we sequenced and phylogenetically analyzed the core region of these type 6 variant subgroups. Serum samples assigned as 6m or 6n by NS5b sequence were also identified as 6 m or 6n by core region analysis. The M6-3 (sample name MYAN-3E-3) remained unassigned to a subgroup based on its core region analysis. The findings of this study suggest that either the core region or the NS5b region can be analyzed for HCV subtype classification. Copyright",

keywords = "HCV core, HCV genotype, Myanmar, Phylogenetic analysis, Type 6 subgroup",

author = "Toshiyuki Shinji and Lwin, {Aye Aye} and Katsunori Gokan and Mikako Obika and Hiromasa Ryuko and Myo Khin and Shigeru Okada and Norio Koide",

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AU - Shinji, Toshiyuki

AU - Lwin, Aye Aye

AU - Gokan, Katsunori

AU - Obika, Mikako

AU - Ryuko, Hiromasa

AU - Khin, Myo

AU - Okada, Shigeru

AU - Koide, Norio

PY - 2006/12

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N2 - Previously, using phylogenetic analysis of NS5b sequences, we found that three type 6 variant subgroups (M6-1, M6-2 and M6-3) exist in Myanmar. According to the new nomenclature of hepatitis C, M6-1 and M6-2 belong to subtypes 6m and 6n, respectively, but M6-3 is unassigned. In this study, we sequenced and phylogenetically analyzed the core region of these type 6 variant subgroups. Serum samples assigned as 6m or 6n by NS5b sequence were also identified as 6 m or 6n by core region analysis. The M6-3 (sample name MYAN-3E-3) remained unassigned to a subgroup based on its core region analysis. The findings of this study suggest that either the core region or the NS5b region can be analyzed for HCV subtype classification. Copyright

AB - Previously, using phylogenetic analysis of NS5b sequences, we found that three type 6 variant subgroups (M6-1, M6-2 and M6-3) exist in Myanmar. According to the new nomenclature of hepatitis C, M6-1 and M6-2 belong to subtypes 6m and 6n, respectively, but M6-3 is unassigned. In this study, we sequenced and phylogenetically analyzed the core region of these type 6 variant subgroups. Serum samples assigned as 6m or 6n by NS5b sequence were also identified as 6 m or 6n by core region analysis. The M6-3 (sample name MYAN-3E-3) remained unassigned to a subgroup based on its core region analysis. The findings of this study suggest that either the core region or the NS5b region can be analyzed for HCV subtype classification. Copyright

KW - HCV core

KW - HCV genotype

KW - Myanmar

KW - Phylogenetic analysis

KW - Type 6 subgroup

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Three type 6 hepatitis C virus subgroups among blood donors in the Yangon area of Myanmar are identified as subtypes 6m and 6n, and a novel subtype by sequence analysis of the core region

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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