Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure Following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer

Hirofumi Makino; Yoshio Nagake; Kazuhiko Moriwaki; Shuzo Hirakawa; Zensuke Ota; Takaaki Katayama; Hiroyuki Yanai; Kiyoshi Takahashi; Tadaatsu Akagi

doi:10.2169/internalmedicine.34.24

Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure Following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer

Hirofumi Makino, Yoshio Nagake, Kazuhiko Moriwaki, Shuzo Hirakawa, Zensuke Ota, Takaaki Katayama, Hiroyuki Yanai, Kiyoshi Takahashi, Tadaatsu Akagi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure. (Internal Medicine 34: 24-27, 1995).

Original language	English
Pages (from-to)	24-27
Number of pages	4
Journal	Internal Medicine
Volume	34
Issue number	1
DOIs	https://doi.org/10.2169/internalmedicine.34.24
Publication status	Published - 1995

Keywords

acute tubular necrosis
microangiopathic hemolytic anemia
myoglobinuria
rhabdomyolysis

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.34.24

Cite this

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title = "Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure Following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer",

abstract = "73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure. (Internal Medicine 34: 24-27, 1995).",

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author = "Hirofumi Makino and Yoshio Nagake and Kazuhiko Moriwaki and Shuzo Hirakawa and Zensuke Ota and Takaaki Katayama and Hiroyuki Yanai and Kiyoshi Takahashi and Tadaatsu Akagi",

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T1 - Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure Following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer

AU - Makino, Hirofumi

AU - Nagake, Yoshio

AU - Moriwaki, Kazuhiko

AU - Hirakawa, Shuzo

AU - Ota, Zensuke

AU - Katayama, Takaaki

AU - Yanai, Hiroyuki

AU - Takahashi, Kiyoshi

AU - Akagi, Tadaatsu

PY - 1995

Y1 - 1995

N2 - 73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure. (Internal Medicine 34: 24-27, 1995).

AB - 73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure. (Internal Medicine 34: 24-27, 1995).

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KW - microangiopathic hemolytic anemia

KW - myoglobinuria

KW - rhabdomyolysis

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Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure Following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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