Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

Megumi Y. Matsumoto; Hidenori Matsuo; Takashi Oka; Takayasu Fukudome; Kazuhiro Hayashi; Hirokazu Shiraishi; Masakatsu Motomura; Noritoshi Shibuya; Hiroyoshi Ayabe

doi:10.1016/j.jneuroim.2004.01.022

Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

Megumi Y. Matsumoto, Hidenori Matsuo, Takashi Oka, Takayasu Fukudome, Kazuhiro Hayashi, Hirokazu Shiraishi, Masakatsu Motomura, Noritoshi Shibuya, Hiroyoshi Ayabe

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We investigated immune property of a myoid cell line, established from Fisher rat thymus. Immunization of syngeneic rats with the myoid cells induced anti-rat acetylcholine receptor (AChR). Implantation of them into the thymus failed to induce typical thymic pathology of human myasthenia gravis (MG) or anti-AChR responses. We also demonstrated that the myoid cells were able to present exogenous antigens to T cells and induce antigen-specific T cell proliferation. These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG.

Original language	English
Pages (from-to)	80-87
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	150
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.01.022
Publication status	Published - May 2004

Keywords

Autoantibody
Germinal center
Myasthenia gravis
Myoid cells
Thymus

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2004.01.022

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title = "Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells",

abstract = "We investigated immune property of a myoid cell line, established from Fisher rat thymus. Immunization of syngeneic rats with the myoid cells induced anti-rat acetylcholine receptor (AChR). Implantation of them into the thymus failed to induce typical thymic pathology of human myasthenia gravis (MG) or anti-AChR responses. We also demonstrated that the myoid cells were able to present exogenous antigens to T cells and induce antigen-specific T cell proliferation. These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG.",

keywords = "Autoantibody, Germinal center, Myasthenia gravis, Myoid cells, Thymus",

author = "Matsumoto, {Megumi Y.} and Hidenori Matsuo and Takashi Oka and Takayasu Fukudome and Kazuhiro Hayashi and Hirokazu Shiraishi and Masakatsu Motomura and Noritoshi Shibuya and Hiroyoshi Ayabe",

note = "Funding Information: We would like to thank Professor N Willcox (University of Oxford) for providing recombinant AChR and his helpful advice on the manuscript. This work was supported by a grant from the Neuroimmunological Disorders Research Committee of the Ministry of Health, Labor and Welfare of Japan. We wish to dedicate this publication to Professor Hiroyoshi Ayabe, who died suddenly after completion of this study.",

year = "2004",

month = may,

doi = "10.1016/j.jneuroim.2004.01.022",

language = "English",

volume = "150",

pages = "80--87",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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TY - JOUR

T1 - Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

AU - Matsumoto, Megumi Y.

AU - Matsuo, Hidenori

AU - Oka, Takashi

AU - Fukudome, Takayasu

AU - Hayashi, Kazuhiro

AU - Shiraishi, Hirokazu

AU - Motomura, Masakatsu

AU - Shibuya, Noritoshi

AU - Ayabe, Hiroyoshi

N1 - Funding Information: We would like to thank Professor N Willcox (University of Oxford) for providing recombinant AChR and his helpful advice on the manuscript. This work was supported by a grant from the Neuroimmunological Disorders Research Committee of the Ministry of Health, Labor and Welfare of Japan. We wish to dedicate this publication to Professor Hiroyoshi Ayabe, who died suddenly after completion of this study.

PY - 2004/5

Y1 - 2004/5

N2 - We investigated immune property of a myoid cell line, established from Fisher rat thymus. Immunization of syngeneic rats with the myoid cells induced anti-rat acetylcholine receptor (AChR). Implantation of them into the thymus failed to induce typical thymic pathology of human myasthenia gravis (MG) or anti-AChR responses. We also demonstrated that the myoid cells were able to present exogenous antigens to T cells and induce antigen-specific T cell proliferation. These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG.

AB - We investigated immune property of a myoid cell line, established from Fisher rat thymus. Immunization of syngeneic rats with the myoid cells induced anti-rat acetylcholine receptor (AChR). Implantation of them into the thymus failed to induce typical thymic pathology of human myasthenia gravis (MG) or anti-AChR responses. We also demonstrated that the myoid cells were able to present exogenous antigens to T cells and induce antigen-specific T cell proliferation. These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG.

KW - Autoantibody

KW - Germinal center

KW - Myasthenia gravis

KW - Myoid cells

KW - Thymus

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DO - 10.1016/j.jneuroim.2004.01.022

M3 - Article

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AN - SCOPUS:1842737780

SN - 0165-5728

VL - 150

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EP - 87

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

Abstract

Keywords

ASJC Scopus subject areas

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