Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

Megumi Y. Matsumoto, Hidenori Matsuo, Takashi Oka, Takayasu Fukudome, Kazuhiro Hayashi, Hirokazu Shiraishi, Masakatsu Motomura, Noritoshi Shibuya, Hiroyoshi Ayabe

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We investigated immune property of a myoid cell line, established from Fisher rat thymus. Immunization of syngeneic rats with the myoid cells induced anti-rat acetylcholine receptor (AChR). Implantation of them into the thymus failed to induce typical thymic pathology of human myasthenia gravis (MG) or anti-AChR responses. We also demonstrated that the myoid cells were able to present exogenous antigens to T cells and induce antigen-specific T cell proliferation. These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - May 2004


  • Autoantibody
  • Germinal center
  • Myasthenia gravis
  • Myoid cells
  • Thymus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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