Abstract
We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.
| Original language | English |
|---|---|
| Pages (from-to) | 57-62 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 783 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2 1998 |
Keywords
- Dentate gyms
- Hippocampus
- Long-term potentiation
- Synapsin I
- mRNA
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology