TY - JOUR
T1 - TIMP-1 and TIMP-2 levels in vitreous and subretinal fluid
AU - Matsuo, Toshihiko
AU - Okada, Yumiko
AU - Shiraga, Fumio
AU - Yanagawa, Toshihiro
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid (B2-09470380) from the Ministry of Education, Science, Sports, and Culture (T. Matsuo), and also by Health Sciences Research Grants, Japan (F. Shiraga). A part of the study was presented as a poster in the 1997 Annual Meeting of the Association for Research in Vision and Ophthalmology.
PY - 1998/9
Y1 - 1998/9
N2 - To understand the role of tissue inhibitors of metalloproteinase-1 and -2 (TIMP-1 and TIMP-2) in intraocular diseases, levels of TIMP-1 and TIMP-2 were measured by enzyme immunoassay in 47 patients with various ocular diseases: in subretinal fluid of 7 patients with rhegmatogenous retinal detachment and in vitreous of 12 patients with proliferative diabetic retinopathy, 4 with proliferative vitreoretinopathy, 2 with vitreous hemorrhage due to branch retinal vein occlusion, 12 with idiopathic macular hole, 3 with retinal detachment due to high-myopic macular hole, 4 with macular epiretinal membrane, and 3 with choroidal neovascular membrane due to age-related macular degeneration. TIMP-1 levels were significantly higher in subretinal fluid than in vitreous fluid with any diseases (P < 0.0001, Mann-Whitney U test). TIMP-1 levels in vitreous fluid of the eyes with proliferative diabetic retinopathy and proliferative vitreoretinopathy were higher than those in vitreous with other diseases (P < 0.0001). In contrast, TIMP-2 levels were not elevated in the subretinal fluid and vitreous. TIMP-1, but not TIMP-2, was secreted into the subretinal space in rhegmatogenous retinal detachment, and also into the vitreous in eyes with proliferative diseases, suggesting that TIMP-1 would play a specific role in the process of these diseases. Copyright (C) 1998 Japanese Ophthalmological Society.
AB - To understand the role of tissue inhibitors of metalloproteinase-1 and -2 (TIMP-1 and TIMP-2) in intraocular diseases, levels of TIMP-1 and TIMP-2 were measured by enzyme immunoassay in 47 patients with various ocular diseases: in subretinal fluid of 7 patients with rhegmatogenous retinal detachment and in vitreous of 12 patients with proliferative diabetic retinopathy, 4 with proliferative vitreoretinopathy, 2 with vitreous hemorrhage due to branch retinal vein occlusion, 12 with idiopathic macular hole, 3 with retinal detachment due to high-myopic macular hole, 4 with macular epiretinal membrane, and 3 with choroidal neovascular membrane due to age-related macular degeneration. TIMP-1 levels were significantly higher in subretinal fluid than in vitreous fluid with any diseases (P < 0.0001, Mann-Whitney U test). TIMP-1 levels in vitreous fluid of the eyes with proliferative diabetic retinopathy and proliferative vitreoretinopathy were higher than those in vitreous with other diseases (P < 0.0001). In contrast, TIMP-2 levels were not elevated in the subretinal fluid and vitreous. TIMP-1, but not TIMP-2, was secreted into the subretinal space in rhegmatogenous retinal detachment, and also into the vitreous in eyes with proliferative diseases, suggesting that TIMP-1 would play a specific role in the process of these diseases. Copyright (C) 1998 Japanese Ophthalmological Society.
KW - Subretinal fluid
KW - TIMP-1
KW - TIMP-2
KW - Vitreous
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U2 - 10.1016/S0021-5155(98)00038-0
DO - 10.1016/S0021-5155(98)00038-0
M3 - Article
C2 - 9822966
AN - SCOPUS:0031789954
SN - 0021-5155
VL - 42
SP - 377
EP - 380
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
IS - 5
ER -
