Tissue Inflammation Impairs Tissue-Level Perfusion and Promotes Left Ventricular Remodeling in Patients With Acute Myocardial Infarction

Yuya Nishida; Hiroshi Ito; Katsuomi Iwakura; Kouji Tanaka; Shigeo Kawano; Atsunori Okamura; Yoshinori Maekawa; Kouichi Inoue; Kenshi Fujii; Masatsugu Hori

doi:10.2303/jecho.3.83

Tissue Inflammation Impairs Tissue-Level Perfusion and Promotes Left Ventricular Remodeling in Patients With Acute Myocardial Infarction

Yuya Nishida, Hiroshi Ito, Katsuomi Iwakura, Kouji Tanaka, Shigeo Kawano, Atsunori Okamura, Yoshinori Maekawa, Kouichi Inoue, Kenshi Fujii, Masatsugu Hori

Research output: Contribution to journal › Article › peer-review

Abstract

Background. C-reactive protein (CRP) level and monocytosis are associated with left ventricular (LV) remodeling in patients with AMI. Methods. One hundred twenty-nine consecutive patients with the first acute myocardial infarction (AMI) underwent myocardial contrast echocardiography (MCE) 2 weeks after successful reperfusion. Results. LV end-diastolic volume index (LVEDVI) at pre-discharge was significantly higher in the no-reflow group than the reflow group (64±17 vs. 58±11 mL/m2, p< 0.01). The no-reflow group had a higher CRP level and peak monocyte counts than the reflow group (9.5±5.2 vs. 5.8±3.5 mg/dl, p<0.0001; and 1026±400 vs. 824±278/μl, p<0.001, respectively). Peak CRP (relative risk [RR] 1.21, 95% confidence interval [CI] 1.01-1.45, p<0.05) and peak monocyte counts (RR 1.003, 95% CI 1.001-1.006, p<0.01) were independent determinants of the no-reflow phenomenon. Conclusion. Microvascular dysfunction following tissue inflammation may play an important role in the LV remodeling after AMI.

Original language	English
Pages (from-to)	83-90
Number of pages	8
Journal	Journal of Echocardiography
Volume	3
Issue number	2
DOIs	https://doi.org/10.2303/jecho.3.83
Publication status	Published - 2005
Externally published	Yes

Keywords

Inflammation
Microcirculation
Monocyte
Myocardial infarction
No-reflow

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2303/jecho.3.83

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@article{493ce3136a5a4f2e9c5482bcfe44fd13,

title = "Tissue Inflammation Impairs Tissue-Level Perfusion and Promotes Left Ventricular Remodeling in Patients With Acute Myocardial Infarction",

abstract = "Background. C-reactive protein (CRP) level and monocytosis are associated with left ventricular (LV) remodeling in patients with AMI. Methods. One hundred twenty-nine consecutive patients with the first acute myocardial infarction (AMI) underwent myocardial contrast echocardiography (MCE) 2 weeks after successful reperfusion. Results. LV end-diastolic volume index (LVEDVI) at pre-discharge was significantly higher in the no-reflow group than the reflow group (64±17 vs. 58±11 mL/m2, p< 0.01). The no-reflow group had a higher CRP level and peak monocyte counts than the reflow group (9.5±5.2 vs. 5.8±3.5 mg/dl, p<0.0001; and 1026±400 vs. 824±278/μl, p<0.001, respectively). Peak CRP (relative risk [RR] 1.21, 95% confidence interval [CI] 1.01-1.45, p<0.05) and peak monocyte counts (RR 1.003, 95% CI 1.001-1.006, p<0.01) were independent determinants of the no-reflow phenomenon. Conclusion. Microvascular dysfunction following tissue inflammation may play an important role in the LV remodeling after AMI.",

keywords = "Inflammation, Microcirculation, Monocyte, Myocardial infarction, No-reflow",

author = "Yuya Nishida and Hiroshi Ito and Katsuomi Iwakura and Kouji Tanaka and Shigeo Kawano and Atsunori Okamura and Yoshinori Maekawa and Kouichi Inoue and Kenshi Fujii and Masatsugu Hori",

year = "2005",

doi = "10.2303/jecho.3.83",

language = "English",

volume = "3",

pages = "83--90",

journal = "Journal of Echocardiography",

issn = "1349-0222",

publisher = "Springer Japan",

number = "2",

}

TY - JOUR

T1 - Tissue Inflammation Impairs Tissue-Level Perfusion and Promotes Left Ventricular Remodeling in Patients With Acute Myocardial Infarction

AU - Nishida, Yuya

AU - Ito, Hiroshi

AU - Iwakura, Katsuomi

AU - Tanaka, Kouji

AU - Kawano, Shigeo

AU - Okamura, Atsunori

AU - Maekawa, Yoshinori

AU - Inoue, Kouichi

AU - Fujii, Kenshi

AU - Hori, Masatsugu

PY - 2005

Y1 - 2005

N2 - Background. C-reactive protein (CRP) level and monocytosis are associated with left ventricular (LV) remodeling in patients with AMI. Methods. One hundred twenty-nine consecutive patients with the first acute myocardial infarction (AMI) underwent myocardial contrast echocardiography (MCE) 2 weeks after successful reperfusion. Results. LV end-diastolic volume index (LVEDVI) at pre-discharge was significantly higher in the no-reflow group than the reflow group (64±17 vs. 58±11 mL/m2, p< 0.01). The no-reflow group had a higher CRP level and peak monocyte counts than the reflow group (9.5±5.2 vs. 5.8±3.5 mg/dl, p<0.0001; and 1026±400 vs. 824±278/μl, p<0.001, respectively). Peak CRP (relative risk [RR] 1.21, 95% confidence interval [CI] 1.01-1.45, p<0.05) and peak monocyte counts (RR 1.003, 95% CI 1.001-1.006, p<0.01) were independent determinants of the no-reflow phenomenon. Conclusion. Microvascular dysfunction following tissue inflammation may play an important role in the LV remodeling after AMI.

AB - Background. C-reactive protein (CRP) level and monocytosis are associated with left ventricular (LV) remodeling in patients with AMI. Methods. One hundred twenty-nine consecutive patients with the first acute myocardial infarction (AMI) underwent myocardial contrast echocardiography (MCE) 2 weeks after successful reperfusion. Results. LV end-diastolic volume index (LVEDVI) at pre-discharge was significantly higher in the no-reflow group than the reflow group (64±17 vs. 58±11 mL/m2, p< 0.01). The no-reflow group had a higher CRP level and peak monocyte counts than the reflow group (9.5±5.2 vs. 5.8±3.5 mg/dl, p<0.0001; and 1026±400 vs. 824±278/μl, p<0.001, respectively). Peak CRP (relative risk [RR] 1.21, 95% confidence interval [CI] 1.01-1.45, p<0.05) and peak monocyte counts (RR 1.003, 95% CI 1.001-1.006, p<0.01) were independent determinants of the no-reflow phenomenon. Conclusion. Microvascular dysfunction following tissue inflammation may play an important role in the LV remodeling after AMI.

KW - Inflammation

KW - Microcirculation

KW - Monocyte

KW - Myocardial infarction

KW - No-reflow

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JO - Journal of Echocardiography

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ER -

Tissue Inflammation Impairs Tissue-Level Perfusion and Promotes Left Ventricular Remodeling in Patients With Acute Myocardial Infarction

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