Tissue Inhibitors of Metalloproteinases (TIMP) in Diabetic Patients

Yoshikazu Hayashi; Hirofumi Makino; Shigeru Morioka; Kenichi Shikata; Zensuke Ota; Yasuo Nagai

doi:10.11213/tonyobyo1958.36.661

Tissue Inhibitors of Metalloproteinases (TIMP) in Diabetic Patients

Yoshikazu Hayashi, Hirofumi Makino, Shigeru Morioka, Kenichi Shikata, Zensuke Ota, Yasuo Nagai

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Abstract

Tissue inhibitors of metalloproteinases (TIMP) play important regulatory roles in degradation of the extracellular matrix (ECM). We measured serum and urinary concentrations of TIMP in diabetic patients and compared the values obtained with those of normal controls. Serum concentrations of TIMP in diabetic patients were not significantly higher than those of control subjects. However, urinary concentrations of TIMP in diabetic patients with proteinuria and renal insufficiency were significantly higher than those of control subjects. Urinary concentrations of TIMP may be increased in patients with advanced diabetic nephropathy. These results suggest that accumulation of glomerular extracellular matrix in diabetes is partly due to increased secretion of TIMP in renal glomeruli.

Original language	English
Pages (from-to)	661-663
Number of pages	3
Journal	Journal of the Japan Diabetes Society
Volume	36
Issue number	8
DOIs	https://doi.org/10.11213/tonyobyo1958.36.661
Publication status	Published - 1993

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.11213/tonyobyo1958.36.661

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abstract = "Tissue inhibitors of metalloproteinases (TIMP) play important regulatory roles in degradation of the extracellular matrix (ECM). We measured serum and urinary concentrations of TIMP in diabetic patients and compared the values obtained with those of normal controls. Serum concentrations of TIMP in diabetic patients were not significantly higher than those of control subjects. However, urinary concentrations of TIMP in diabetic patients with proteinuria and renal insufficiency were significantly higher than those of control subjects. Urinary concentrations of TIMP may be increased in patients with advanced diabetic nephropathy. These results suggest that accumulation of glomerular extracellular matrix in diabetes is partly due to increased secretion of TIMP in renal glomeruli.",

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AU - Hayashi, Yoshikazu

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AU - Ota, Zensuke

AU - Nagai, Yasuo

PY - 1993

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AB - Tissue inhibitors of metalloproteinases (TIMP) play important regulatory roles in degradation of the extracellular matrix (ECM). We measured serum and urinary concentrations of TIMP in diabetic patients and compared the values obtained with those of normal controls. Serum concentrations of TIMP in diabetic patients were not significantly higher than those of control subjects. However, urinary concentrations of TIMP in diabetic patients with proteinuria and renal insufficiency were significantly higher than those of control subjects. Urinary concentrations of TIMP may be increased in patients with advanced diabetic nephropathy. These results suggest that accumulation of glomerular extracellular matrix in diabetes is partly due to increased secretion of TIMP in renal glomeruli.

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Tissue Inhibitors of Metalloproteinases (TIMP) in Diabetic Patients

Abstract

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