TY - JOUR
T1 - Titanium as an Instant Adhesive for Biological Soft Tissue
AU - Okada, Masahiro
AU - Hara, Emilio Satoshi
AU - Yabe, Atsushi
AU - Okada, Kei
AU - Shibata, Yo
AU - Torii, Yasuhiro
AU - Nakano, Takayoshi
AU - Matsumoto, Takuya
N1 - Funding Information:
The authors thank Yagishita Giken Co. Ltd. (Saitama, Japan) for supporting the fabrication of acid-treated titanium films. This work was supported partly by the Japan Society for the Promotion of Science KAKENHI (Grant Numbers: 18K09637, JP25220912, and JP25293402).
Funding Information:
The authors thank Yagishita Giken Co. Ltd. (Saitama, Japan) for supporting the fabrication of acid‐treated titanium films. This work was supported partly by the Japan Society for the Promotion of Science KAKENHI (Grant Numbers: 18K09637, JP25220912, and JP25293402).
Publisher Copyright:
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/5/1
Y1 - 2020/5/1
N2 - A variety of polymer- and ceramic-based soft-tissue adhesives have been developed as alternatives to surgical sutures, yet several disadvantages regarding the mechanical properties, biocompatibility, and handling hinder their further application particularly when applied for immobilization of implantable devices. Here, it is reported that a biocompatible and tough metal, titanium (Ti), shows instant and remarkable adhesion properties after acid treatment, demonstrated by ex vivo shear adhesion tests with mouse dermal tissues. Importantly, in vivo experiments demonstrate that the acid-treated Ti can easily and stably immobilize a device implanted in the mouse subcutaneous tissue. Collectively, the acid-treated Ti is shown as a solid-state instant adhesive material for biological soft tissues, which can have diverse applications including immobilization of body-implantable devices.
AB - A variety of polymer- and ceramic-based soft-tissue adhesives have been developed as alternatives to surgical sutures, yet several disadvantages regarding the mechanical properties, biocompatibility, and handling hinder their further application particularly when applied for immobilization of implantable devices. Here, it is reported that a biocompatible and tough metal, titanium (Ti), shows instant and remarkable adhesion properties after acid treatment, demonstrated by ex vivo shear adhesion tests with mouse dermal tissues. Importantly, in vivo experiments demonstrate that the acid-treated Ti can easily and stably immobilize a device implanted in the mouse subcutaneous tissue. Collectively, the acid-treated Ti is shown as a solid-state instant adhesive material for biological soft tissues, which can have diverse applications including immobilization of body-implantable devices.
KW - acid treatment
KW - adhesive
KW - hydrophobic interaction
KW - soft tissue
KW - titanium
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U2 - 10.1002/admi.201902089
DO - 10.1002/admi.201902089
M3 - Article
AN - SCOPUS:85082880815
SN - 2196-7350
VL - 7
JO - Advanced Materials Interfaces
JF - Advanced Materials Interfaces
IS - 9
M1 - 1902089
ER -