Total synthesis of gambierol

Isao Kadota; Hiroyoshi Takamura; Kumi Sato; Akio Ohno; Kumiko Matsuda; Yoshinori Yamamoto

doi:10.1021/ja028726d

Total synthesis of gambierol

Isao Kadota, Hiroyoshi Takamura, Kumi Sato, Akio Ohno, Kumiko Matsuda, Yoshinori Yamamoto

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of α-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain.

Original language	English
Pages (from-to)	46-47
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	1
DOIs	https://doi.org/10.1021/ja028726d
Publication status	Published - Jan 8 2003
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja028726d

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title = "Total synthesis of gambierol",

abstract = "The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of α-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain.",

author = "Isao Kadota and Hiroyoshi Takamura and Kumi Sato and Akio Ohno and Kumiko Matsuda and Yoshinori Yamamoto",

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AU - Takamura, Hiroyoshi

AU - Sato, Kumi

AU - Ohno, Akio

AU - Matsuda, Kumiko

AU - Yamamoto, Yoshinori

PY - 2003/1/8

Y1 - 2003/1/8

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AB - The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of α-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain.

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Total synthesis of gambierol

Abstract

ASJC Scopus subject areas

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