Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation

Medicine & Life Sciences

• 13-oxyingenol 100%
• Protein Kinase C 32%
• HL-60 Cells 22%
• ingenol 18%
• Laurates 16%
• protein kinase C kinase 13%
• Cell Differentiation 7%
• hexanoic acid 7%
• Alkenes 7%
• Protein C Inhibitor 5%
• Phorbol Esters 5%
• Protein Kinase Inhibitors 5%
• Isoenzymes 4%
• Phosphotransferases 3%
• Cell Death 3%
• Macrophages 3%
• Phenotype 2%
• In Vitro Techniques 2%

Physics & Astronomy

• analogs 31%
• proteins 30%
• synthesis 27%
• evaluation 24%
• activation 10%
• cells 9%
• metathesis 7%
• macrophages 6%
• phenotype 6%
• alkenes 5%
• inhibitors 5%
• closing 4%
• death 4%
• esters 4%
• methodology 3%
• rings 2%

Chemical Compounds

• Total Synthesis 33%
• Ingenol 17%
• Protein 16%
• Dodecanoyl Group 10%
• Protein Kinase C Inhibitor 7%
• Phorbol Ester 6%
• Olefin Metathesis 5%
• Cell Death 5%
• Hydroxy Group 4%
• Metathesis Reaction 4%