Total Synthesis of Sarcophytonolide H and Isosarcophytonolide D: Structural Revision of Isosarcophytonolide D and Structure-Antifouling Activity Relationship of Sarcophytonolide H

Hiroyoshi Takamura; Takahiro Kikuchi; Noriyuki Endo; Yuji Fukuda; Isao Kadota

doi:10.1021/acs.orglett.6b00737

Total Synthesis of Sarcophytonolide H and Isosarcophytonolide D: Structural Revision of Isosarcophytonolide D and Structure-Antifouling Activity Relationship of Sarcophytonolide H

Hiroyoshi Takamura, Takahiro Kikuchi, Noriyuki Endo, Yuji Fukuda, Isao Kadota

School of Science

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The first total syntheses of sarcophytonolide H and the originally proposed and correct structures of isosarcophytonolide D have been achieved via transannular ring-closing metathesis (RCM). These total syntheses culminated in the stereostructural confirmation of sarcophytonolide H and the reassignment of isosarcophytonolide D, respectively. The antifouling activity of the synthetic sarcophytonolide H and its analogues was also evaluated.

Original language	English
Pages (from-to)	2110-2113
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	9
DOIs	https://doi.org/10.1021/acs.orglett.6b00737
Publication status	Published - May 6 2016

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.6b00737

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Total Synthesis of Sarcophytonolide H and Isosarcophytonolide D: Structural Revision of Isosarcophytonolide D and Structure-Antifouling Activity Relationship of Sarcophytonolide H. / Takamura, Hiroyoshi; Kikuchi, Takahiro; Endo, Noriyuki et al.
In: Organic Letters, Vol. 18, No. 9, 06.05.2016, p. 2110-2113.

Research output: Contribution to journal › Article › peer-review

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AU - Kadota, Isao

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Total Synthesis of Sarcophytonolide H and Isosarcophytonolide D: Structural Revision of Isosarcophytonolide D and Structure-Antifouling Activity Relationship of Sarcophytonolide H

Abstract

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