Total Synthesis of Scabrolide F

Hiroyoshi Takamura, Yuki Sugitani, Ryohei Morishita, Isao Kadota

Research output: Contribution to journalArticlepeer-review


The first total synthesis of scabrolide F, a norcembranolide isolated from the soft coral Sinularia scabra, is described. Hydroxycarboxylic acid, which is the key synthetic intermediate, was synthesized in a convergent manner by fragment coupling. The obtained hydroxycarboxylic acid was subjected to macrolactonization and subsequent transannular ring-closing metathesis (RCM) to furnish scabrolide F. The synthetic protocol can be extended to the total synthesis of other norcembranolides.

Original languageEnglish
JournalOrganic Letters
Publication statusAccepted/In press - 2022

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Total Synthesis of Scabrolide F'. Together they form a unique fingerprint.

Cite this