Toward the second generation synthesis of aplyronine A: Stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling

Kenichi Kobayashi; Yusuke Fujii; Ichiro Hayakawa; Hideo Kigoshi

doi:10.1021/ol1029657

Toward the second generation synthesis of aplyronine A: Stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling

Kenichi Kobayashi, Yusuke Fujii, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E)-trisubstituted double bond and the C13 stereocenter was achieved by using an asymmetric Nozaki-Hiyama-Kishi coupling.(Figure Presented)

Original language	English
Pages (from-to)	900-903
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	5
DOIs	https://doi.org/10.1021/ol1029657
Publication status	Published - Mar 4 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1029657

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abstract = "An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E)-trisubstituted double bond and the C13 stereocenter was achieved by using an asymmetric Nozaki-Hiyama-Kishi coupling.(Figure Presented)",

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AU - Kobayashi, Kenichi

AU - Fujii, Yusuke

AU - Hayakawa, Ichiro

AU - Kigoshi, Hideo

PY - 2011/3/4

Y1 - 2011/3/4

N2 - An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E)-trisubstituted double bond and the C13 stereocenter was achieved by using an asymmetric Nozaki-Hiyama-Kishi coupling.(Figure Presented)

AB - An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E)-trisubstituted double bond and the C13 stereocenter was achieved by using an asymmetric Nozaki-Hiyama-Kishi coupling.(Figure Presented)

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Toward the second generation synthesis of aplyronine A: Stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling

Abstract

ASJC Scopus subject areas

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