Transcriptional trans-repression by the c-myb proto-oncogene product

Hideki Nakagoshi, Takahiro Nagase, Yoshio Ueno, Shunsuke Ishii

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


We report that the c-myb protein binds to another site, MBS-l1, in the SV4O enhancer with low affinity. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of the sequence containing the MBS-I1 site induced c-myb-dependent transcriptional repression. Results of mutational analyses of the sequence around the MBS-II site suggested that the c-myb protein represses transcription by competing with another trans-activator. These results indicate the c-myb protein can regulate transcription not only positively but also negatively.

Original languageEnglish
Pages (from-to)7315-7324
Number of pages10
JournalNucleic acids research
Issue number18
Publication statusPublished - Sept 25 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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