Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia

Norio Shiba; Kenichi Yoshida; Yusuke Hara; Genki Yamato; Yuichi Shiraishi; Hidemasa Matsuo; Yusuke Okuno; Kenichi Chiba; Hiroko Tanaka; Taeko Kaburagi; Masanobu Takeuchi; Kentaro Ohki; Masashi Sanada; Jun Okubo; Daisuke Tomizawa; Tomohiko Taki; Akira Shimada; Manabu Sotomatsu; Keizo Horibe; Takashi Taga; Souichi Adachi; Akio Tawa; Satoru Miyano; Seishi Ogawa; Yasuhide Hayashi

doi:10.1182/bloodadvances.2019000404

Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia

Norio Shiba, Kenichi Yoshida, Yusuke Hara, Genki Yamato, Yuichi Shiraishi, Hidemasa Matsuo, Yusuke Okuno, Kenichi Chiba, Hiroko Tanaka, Taeko Kaburagi, Masanobu Takeuchi, Kentaro Ohki, Masashi Sanada, Jun Okubo, Daisuke Tomizawa, Tomohiko Taki, Akira Shimada, Manabu Sotomatsu, Keizo Horibe, Takashi TagaSouichi Adachi, Akio Tawa, Satoru Miyano, Seishi Ogawa, Yasuhide Hayashi

University Hospital

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Original language	English
Pages (from-to)	3157-3169
Number of pages	13
Journal	Blood Advances
Volume	3
Issue number	20
DOIs	https://doi.org/10.1182/bloodadvances.2019000404
Publication status	Published - Oct 22 2019

ASJC Scopus subject areas

Hematology

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10.1182/bloodadvances.2019000404

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Shiba, N., Yoshida, K., Hara, Y., Yamato, G., Shiraishi, Y., Matsuo, H., Okuno, Y., Chiba, K., Tanaka, H., Kaburagi, T., Takeuchi, M., Ohki, K., Sanada, M., Okubo, J., Tomizawa, D., Taki, T., Shimada, A., Sotomatsu, M., Horibe, K., ... Hayashi, Y. (2019). Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia. Blood Advances, 3(20), 3157-3169. https://doi.org/10.1182/bloodadvances.2019000404

Shiba, N, Yoshida, K, Hara, Y, Yamato, G, Shiraishi, Y, Matsuo, H, Okuno, Y, Chiba, K, Tanaka, H, Kaburagi, T, Takeuchi, M, Ohki, K, Sanada, M, Okubo, J, Tomizawa, D, Taki, T, Shimada, A, Sotomatsu, M, Horibe, K, Taga, T, Adachi, S, Tawa, A, Miyano, S, Ogawa, S & Hayashi, Y 2019, 'Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia', Blood Advances, vol. 3, no. 20, pp. 3157-3169. https://doi.org/10.1182/bloodadvances.2019000404

@article{50193e06fc564a8cbf37df178f464459,

title = "Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia",

author = "Norio Shiba and Kenichi Yoshida and Yusuke Hara and Genki Yamato and Yuichi Shiraishi and Hidemasa Matsuo and Yusuke Okuno and Kenichi Chiba and Hiroko Tanaka and Taeko Kaburagi and Masanobu Takeuchi and Kentaro Ohki and Masashi Sanada and Jun Okubo and Daisuke Tomizawa and Tomohiko Taki and Akira Shimada and Manabu Sotomatsu and Keizo Horibe and Takashi Taga and Souichi Adachi and Akio Tawa and Satoru Miyano and Seishi Ogawa and Yasuhide Hayashi",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Health, Labor and Welfare of Japan (15H05909) (S.O.), a grant for project for development of innovative research on cancer therapeutics (P-DIRECT) from the Japan Agency for Medical Research and Development (AMED; JP18ck0106250h0002) (S.O.), the Practical Research for Innovative Cancer Control from AMED (15ck0106066h0002) (M.S.), a grant for project for cancer research and therapeutics evolution (P-CREATE) from AMED (JP18cm0106501h0003) (S.O.), the Japan Society for the Promotion of Science (KAKENHI grants 25893028 [N.S.], 15H05909 [S.O.], 16K20951 [N.S.], and 17K10130 [N.S.]), a research grant from the Japanese Society of Hematology, and the Kawano Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics. Funding Information: 1Department of Pediatrics, Yokohama City University Hospital, Yokohama, Japan; 2Department of Hematology/Oncology, Gunma Children{\textquoteright}s Medical Center, Shibukawa, Japan; 3Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan; 4Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 5Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan; 6Center for Cancer Genomics and Advanced Therapeutics, National Cancer Center, Tokyo, Japan; 7Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan; 8Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan; 9Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan; 10Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan; 11Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 12Division of Leukemia and Lymphoma, Children{\textquoteright}s Cancer Center, National Center for Child Health and Development, Tokyo, Japan; 13Department of Medical Technology, Kyorin University Faculty of Health Sciences, Mitaka, Japan; 14Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan; 15Department of Pediatrics, Shiga University of Medical Science, Ohtsu, Japan; 16Department of Pediatrics, National Hospital Organization Osaka National Hospital, Osaka, Japan; 17Laboratory of DNA Information, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan; 18Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan; 19Department of Medicine, Centre for Haematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden; and 20Institute of Physiology and Medicine, Jobu University, Takasaki, Japan Funding Information: The authors thank Yuki Hoshino for her valuable technical assistance. The authors would like to thank Enago (www.enago.jp) for the English language review. Supercomputing resources were provided by the Human Genome Center, Institute of Medical Science, The University of Tokyo. This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Health, Labor and Welfare of Japan (15H05909) (S.O.), a grant for project for development of innovative research on cancer therapeutics (P-DIRECT) from the Japan Agency for Medical Research and Development (AMED; JP18ck0106250h0002) (S.O.), the Practical Research for Innovative Cancer Control from AMED (15ck0106066h0002) (M.S.), a grant for project for cancer research and therapeutics evolution (P-CREATE) from AMED (JP18cm0106501h0003) (S.O.), the Japan Society for the Promotion of Science (KAKENHI grants 25893028 [N.S.], 15H05909 [S.O.], 16K20951 [N.S.], and 17K10130 [N.S.]), a research grant from the Japanese Society of Hematology, and the Kawano Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics.",

year = "2019",

month = oct,

day = "22",

doi = "10.1182/bloodadvances.2019000404",

language = "English",

volume = "3",

pages = "3157--3169",

journal = "Blood advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

number = "20",

}

TY - JOUR

T1 - Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia

AU - Shiba, Norio

AU - Yoshida, Kenichi

AU - Hara, Yusuke

AU - Yamato, Genki

AU - Shiraishi, Yuichi

AU - Matsuo, Hidemasa

AU - Okuno, Yusuke

AU - Chiba, Kenichi

AU - Tanaka, Hiroko

AU - Kaburagi, Taeko

AU - Takeuchi, Masanobu

AU - Ohki, Kentaro

AU - Sanada, Masashi

AU - Okubo, Jun

AU - Tomizawa, Daisuke

AU - Taki, Tomohiko

AU - Shimada, Akira

AU - Sotomatsu, Manabu

AU - Horibe, Keizo

AU - Taga, Takashi

AU - Adachi, Souichi

AU - Tawa, Akio

AU - Miyano, Satoru

AU - Ogawa, Seishi

AU - Hayashi, Yasuhide

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Health, Labor and Welfare of Japan (15H05909) (S.O.), a grant for project for development of innovative research on cancer therapeutics (P-DIRECT) from the Japan Agency for Medical Research and Development (AMED; JP18ck0106250h0002) (S.O.), the Practical Research for Innovative Cancer Control from AMED (15ck0106066h0002) (M.S.), a grant for project for cancer research and therapeutics evolution (P-CREATE) from AMED (JP18cm0106501h0003) (S.O.), the Japan Society for the Promotion of Science (KAKENHI grants 25893028 [N.S.], 15H05909 [S.O.], 16K20951 [N.S.], and 17K10130 [N.S.]), a research grant from the Japanese Society of Hematology, and the Kawano Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics. Funding Information: 1Department of Pediatrics, Yokohama City University Hospital, Yokohama, Japan; 2Department of Hematology/Oncology, Gunma Children’s Medical Center, Shibukawa, Japan; 3Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan; 4Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 5Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan; 6Center for Cancer Genomics and Advanced Therapeutics, National Cancer Center, Tokyo, Japan; 7Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan; 8Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan; 9Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan; 10Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan; 11Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 12Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan; 13Department of Medical Technology, Kyorin University Faculty of Health Sciences, Mitaka, Japan; 14Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan; 15Department of Pediatrics, Shiga University of Medical Science, Ohtsu, Japan; 16Department of Pediatrics, National Hospital Organization Osaka National Hospital, Osaka, Japan; 17Laboratory of DNA Information, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan; 18Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan; 19Department of Medicine, Centre for Haematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden; and 20Institute of Physiology and Medicine, Jobu University, Takasaki, Japan Funding Information: The authors thank Yuki Hoshino for her valuable technical assistance. The authors would like to thank Enago (www.enago.jp) for the English language review. Supercomputing resources were provided by the Human Genome Center, Institute of Medical Science, The University of Tokyo. This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Health, Labor and Welfare of Japan (15H05909) (S.O.), a grant for project for development of innovative research on cancer therapeutics (P-DIRECT) from the Japan Agency for Medical Research and Development (AMED; JP18ck0106250h0002) (S.O.), the Practical Research for Innovative Cancer Control from AMED (15ck0106066h0002) (M.S.), a grant for project for cancer research and therapeutics evolution (P-CREATE) from AMED (JP18cm0106501h0003) (S.O.), the Japan Society for the Promotion of Science (KAKENHI grants 25893028 [N.S.], 15H05909 [S.O.], 16K20951 [N.S.], and 17K10130 [N.S.]), a research grant from the Japanese Society of Hematology, and the Kawano Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics.

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Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia

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