Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens

Hirotaka Shibuya; Chinami Kitamura; Shoji Maehara; Marie Nagahata; Hendig Winarno; Partomuan Simanjuntak; Hye Sook Kim; Yusuke Wataya; Kazuyoshi Ohashi

doi:10.1248/cpb.51.71

Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens

Hirotaka Shibuya, Chinami Kitamura, Shoji Maehara, Marie Nagahata, Hendig Winarno, Partomuan Simanjuntak, Hye Sook Kim, Yusuke Wataya, Kazuyoshi Ohashi

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

Original language	English
Pages (from-to)	71-74
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	51
Issue number	1
DOIs	https://doi.org/10.1248/cpb.51.71
Publication status	Published - Jan 2003

Keywords

Antimalarial activity
Cinchona alkaloid
Cinchona pubescens
Endophyte
Microbial transformation
Xylaria sp.

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.51.71

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title = "Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens",

abstract = "The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.",

keywords = "Antimalarial activity, Cinchona alkaloid, Cinchona pubescens, Endophyte, Microbial transformation, Xylaria sp.",

author = "Hirotaka Shibuya and Chinami Kitamura and Shoji Maehara and Marie Nagahata and Hendig Winarno and Partomuan Simanjuntak and Kim, {Hye Sook} and Yusuke Wataya and Kazuyoshi Ohashi",

year = "2003",

month = jan,

doi = "10.1248/cpb.51.71",

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T1 - Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens

AU - Shibuya, Hirotaka

AU - Kitamura, Chinami

AU - Maehara, Shoji

AU - Nagahata, Marie

AU - Winarno, Hendig

AU - Simanjuntak, Partomuan

AU - Kim, Hye Sook

AU - Wataya, Yusuke

AU - Ohashi, Kazuyoshi

PY - 2003/1

Y1 - 2003/1

N2 - The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

AB - The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

KW - Antimalarial activity

KW - Cinchona alkaloid

KW - Cinchona pubescens

KW - Endophyte

KW - Microbial transformation

KW - Xylaria sp.

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SN - 0009-2363

VL - 51

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EP - 74

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 1

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Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens

Abstract

Keywords

ASJC Scopus subject areas

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