Transmural cellular heterogeneity in myocardial electromechanics

Anastasia Khokhlova, Nathalie Balakina-Vikulova, Leonid Katsnelson, Gentaro Iribe, Olga Solovyova

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.

Original languageEnglish
Pages (from-to)387-413
Number of pages27
JournalJournal of Physiological Sciences
Issue number4
Publication statusPublished - Jul 1 2018


  • Cardiac modeling
  • Cardiac transmural heterogeneity
  • Cardiomyocyte
  • Electromechanical coupling
  • Mechano-calcium-electric feedback

ASJC Scopus subject areas

  • Physiology


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